CKDkb: a knowledge base and platform for drug development against non-alcoholic fatty liver disease

Structure:

CMap ID:	C05286
Pert ID:	BRD-K48195801
Compound Name:	tecastemizole
Targets:	KCNH2
MoA:	histamine receptor antagonist
SMILES:	Fc1ccc(Cn2c(NC3CCNCC3)nc3ccccc23)cc1
InchiKey:
Compound Aliases:

The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).
Score ID	Pert ID	Cell Line	Pert Dose	Pert Time	Raw Score (GSE126848)	Normalized Score (GSE126848)	fdr_q_nlog10 (GSE126848)	Raw Score (GSE135251)	Normalized Score (GSE135251)	fdr_q_nlog10 (GSE135251)
125258	BRD-K48195801	A549	1.11 uM	24 h	-0.25	-1.03	0.2	0.0	0.0	0.0
125280	BRD-K48195801	HA1E	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
125315	BRD-K48195801	HEK293	0.04 uM	24 h	0.2	0.83	0.0	0.34	1.21	1.15
125398	BRD-K48195801	JURKAT	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
125415	BRD-K48195801	MCF10A	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
125447	BRD-K48195801	MCF??7.00	3.33 uM	24 h	0.0	0.0	0.0	0.33	1.17	0.95
125519	BRD-K48195801	THP1	10 uM	24 h	0.0	0.0	0.0	-0.33	-1.12	0.95
125547	BRD-K48195801	YAPC	0.04 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
133341	BRD-K48195801	A375	2.22 uM	24 h	-0.24	-0.99	0.13	-0.31	-1.04	0.67
133424	BRD-K48195801	HELA	2.22 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
133457	BRD-K48195801	HT29	2.22 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
133555	BRD-K48195801	MDAMB231	0.03 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
133583	BRD-K48195801	PC3	0.74 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0

Summary