CKDkb: a knowledge base and platform for drug development against non-alcoholic fatty liver disease

Structure:

CMap ID:	C05297
Pert ID:	BRD-K84564571
Compound Name:	telatinib
Targets:	KDR
MoA:	KIT inhibitor; PDGFR tyrosine kinase receptor inhibitor; VEGFR inhibitor
SMILES:	CNC(=O)c1cc(COc2nnc(Nc3ccc(Cl)cc3)c3ccoc23)ccn1
InchiKey:
Compound Aliases:

The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).
Score ID	Pert ID	Cell Line	Pert Dose	Pert Time	Raw Score (GSE126848)	Normalized Score (GSE126848)	fdr_q_nlog10 (GSE126848)	Raw Score (GSE135251)	Normalized Score (GSE135251)	fdr_q_nlog10 (GSE135251)
125562	BRD-K84564571	A375	0.37 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
125625	BRD-K84564571	HA1E	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
125711	BRD-K84564571	HUVEC	10 uM	24 h	0.0	0.0	0.0	-0.3	-1.0	0.54
125793	BRD-K84564571	MCF10A	3.33 uM	24 h	-0.32	-1.34	0.98	0.0	0.0	0.0
125818	BRD-K84564571	MCF??7.00	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
125842	BRD-K84564571	MDAMB231	1.11 uM	24 h	0.0	0.0	0.0	0.42	1.5	2.26
125864	BRD-K84564571	PC3	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
125888	BRD-K84564571	THP1	1.11 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
125910	BRD-K84564571	YAPC	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
133657	BRD-K84564571	A549	0.74 uM	24 h	0.0	0.0	0.0	-0.27	-0.91	0.31
133724	BRD-K84564571	HEK293	2.22 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
133751	BRD-K84564571	HELA	0.03 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
133784	BRD-K84564571	HT29	2.22 uM	24 h	0.0	0.0	0.0	-0.2	-0.69	0.02
133817	BRD-K84564571	JURKAT	0.03 uM	24 h	-0.29	-1.22	0.6	0.32	1.12	0.76

Summary