CMap Candidate Details
Structure:
| CMap ID: | C05299 |
| Pert ID: | BRD-K91159026 |
| Compound Name: | telcagepant |
| Targets: | CALCRL|RAMP1 |
| MoA: | calcitonin antagonist |
| SMILES: | Fc1cccc([C@@H]2CC[C@@H](NC(=O)N3CCC(CC3)n3c4cccnc4[nH]c3=O)C(=O)N(CC(F)(F)F)C2)c1F |
| InchiKey: | |
| Compound Aliases: |
| Score ID | Pert ID | Cell Line | Pert Dose | Pert Time | Raw Score (GSE126848) | Normalized Score (GSE126848) | fdr_q_nlog10 (GSE126848) | Raw Score (GSE135251) | Normalized Score (GSE135251) | fdr_q_nlog10 (GSE135251) |
|---|---|---|---|---|---|---|---|---|---|---|
| 127740 | BRD-K91159026 | A375 | 0.125 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 127784 | BRD-K91159026 | A549 | 1.11 uM | 24 h | 0.24 | 1.0 | 0.11 | 0.35 | 1.23 | 1.19 |
| 127820 | BRD-K91159026 | HA1E | 3.33 uM | 24 h | 0.0 | 0.0 | 0.0 | -0.29 | -0.99 | 0.5 |
| 127864 | BRD-K91159026 | HEK293 | 0.37 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 127899 | BRD-K91159026 | HT29 | 3.33 uM | 24 h | 0.0 | 0.0 | 0.0 | -0.26 | -0.87 | 0.23 |
| 127938 | BRD-K91159026 | HUVEC | 1.11 uM | 24 h | 0.31 | 1.31 | 0.75 | 0.0 | 0.0 | 0.0 |
| 127991 | BRD-K91159026 | MCF10A | 10 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 128027 | BRD-K91159026 | MCF??7.00 | 0.37 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 128077 | BRD-K91159026 | YAPC | 0.125 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 135565 | BRD-K91159026 | HELA | 0.01 uM | 24 h | 0.26 | 1.09 | 0.23 | 0.0 | 0.0 | 0.0 |
| 135656 | BRD-K91159026 | JURKAT | 0.08 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 135718 | BRD-K91159026 | PC3 | 0.08 uM | 24 h | -0.16 | -0.68 | 0.0 | 0.0 | 0.0 | 0.0 |