CMap Candidate Details
Structure:
| CMap ID: | C05312 |
| Pert ID: | BRD-K42898655 |
| Compound Name: | temsirolimus |
| Targets: | MTOR |
| MoA: | mTOR inhibitor |
| SMILES: | CO[C@@H]1C[C@H](C[C@@H](C)[C@@H]2CC(=O)[C@H](C)\C=C(C)\[C@@H](O)[C@@H](OC)C(=O)[C@H](C)C[C@H](C)\C=C\C=C\C=C(C)\[C@H](C[C@H]3CC[C@@H](C)[C@@](O)(O3)C(=O)C(=O)N3CCCC[C@H]3C(=O)O2)OC)CC[C@@H]1OC(=O)C(C)(CO)CO |
| InchiKey: | |
| Compound Aliases: |
| Score ID | Pert ID | Cell Line | Pert Dose | Pert Time | Raw Score (GSE126848) | Normalized Score (GSE126848) | fdr_q_nlog10 (GSE126848) | Raw Score (GSE135251) | Normalized Score (GSE135251) | fdr_q_nlog10 (GSE135251) |
|---|---|---|---|---|---|---|---|---|---|---|
| 121578 | BRD-K42898655 | HA1E | 10 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 129573 | BRD-K42898655 | A375 | 2.22 uM | 24 h | 0.18 | 0.74 | 0.0 | 0.0 | 0.0 | 0.0 |
| 129592 | BRD-K42898655 | HELA | 0.01 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 129620 | BRD-K42898655 | HT29 | 0.03 uM | 24 h | 0.0 | 0.0 | 0.0 | -0.28 | -0.96 | 0.43 |
| 129650 | BRD-K42898655 | MCF??7.00 | 0.74 uM | 24 h | 0.0 | 0.0 | 0.0 | -0.39 | -1.33 | 1.72 |
| 129672 | BRD-K42898655 | PC3 | 0.03 uM | 24 h | 0.0 | 0.0 | 0.0 | -0.26 | -0.86 | 0.22 |
| 129713 | BRD-K42898655 | YAPC | 2.22 uM | 24 h | 0.0 | 0.0 | 0.0 | -0.28 | -0.95 | 0.42 |