CKDkb: a knowledge base and platform for drug development against non-alcoholic fatty liver disease

Structure:

CMap ID:	C05321
Pert ID:	BRD-K05977823
Compound Name:	tenovin-1
Targets:	SIRT1
MoA:	SIRT inhibitor; TP53 activator
SMILES:	CC(=O)Nc1ccc(NC(=S)NC(=O)c2ccc(cc2)C(C)(C)C)cc1
InchiKey:
Compound Aliases:

The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).
Score ID	Pert ID	Cell Line	Pert Dose	Pert Time	Raw Score (GSE126848)	Normalized Score (GSE126848)	fdr_q_nlog10 (GSE126848)	Raw Score (GSE135251)	Normalized Score (GSE135251)	fdr_q_nlog10 (GSE135251)
33642	BRD-K05977823	A375	10 uM	6 h	-0.25	-1.04	0.22	0.0	0.0	0.0
33769	BRD-K05977823	A549	10 uM	24 h	0.0	0.0	0.0	-0.32	-1.09	0.82
34033	BRD-K05977823	ASC	10 uM	24 h	-0.34	-1.4	1.14	0.0	0.0	0.0
34305	BRD-K05977823	HA1E	10 uM	6 h	0.0	0.0	0.0	0.0	0.0	0.0
34547	BRD-K05977823	HCC515	10 uM	6 h	0.0	0.0	0.0	0.0	0.0	0.0
34816	BRD-K05977823	HEPG2	10 uM	6 h	-0.26	-1.08	0.29	0.0	0.0	0.0
35083	BRD-K05977823	HT29	10 uM	6 h	0.0	0.0	0.0	0.0	0.0	0.0
35292	BRD-K05977823	MCF??7.00	10 uM	24 h	0.0	0.0	0.0	0.28	1.01	0.44
35719	BRD-K05977823	NPC	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
35926	BRD-K05977823	PC3	10 uM	24 h	-0.2	-0.85	0.01	0.28	0.98	0.39
36191	BRD-K05977823	PHH	10 uM	24 h	0.0	0.0	0.0	-0.35	-1.19	1.15
36484	BRD-K05977823	SKB	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
36944	BRD-K05977823	VCAP	10 uM	6 h	0.23	0.94	0.06	0.0	0.0	0.0

Summary