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CMap Candidate Details

Structure:
CMap ID: C05326
Pert ID: BRD-A18279961
Compound Name: TEPP-46
Targets: PKM
MoA: pyruvate kinase isozyme activator
SMILES: Cn1c2cc(sc2c2cnn(Cc3cccc(N)c3)c(=O)c12)S(C)=O
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
16532 BRD-A18279961 A549 10 uM 6 h 0.23 0.96 0.08 0.0 0.0 0.0
16857 BRD-A18279961 HCC515 10 uM 6 h 0.0 0.0 0.0 -0.4 -1.35 2.01
17184 BRD-A18279961 HEPG2 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
17522 BRD-A18279961 HT29 10 uM 6 h 0.0 0.0 0.0 -0.24 -0.81 0.14
17866 BRD-A18279961 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
18658 BRD-A18279961 VCAP 10 uM 6 h 0.0 0.0 0.0 -0.31 -1.03 0.62
96850 BRD-A18279961 A375 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
96927 BRD-A18279961 PC3 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).