Logo 1 Logo 2

CMap Candidate Details

Structure:
CMap ID: C05397
Pert ID: BRD-A84481105
Compound Name: thioridazine
Targets: ADRA1A|ADRA1B|DRD1|DRD2|DRD3|DRD4|DRD5|HRH1|HTR1A|HTR2A|HTR2C|HTR6|HTR7|KCNH2
MoA: dopamine receptor antagonist
SMILES: CSc1ccc2Sc3ccccc3N(CCC3CCCCN3C)c2c1
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
1169 BRD-A84481105 MCF??7.00 10 uM 24 h -0.2 -0.82 0.0 0.0 0.0 0.0
1209 BRD-A84481105 PC3 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
6705 BRD-A84481105 A375 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
7601 BRD-A84481105 HCC515 10 uM 6 h 0.0 0.0 0.0 0.42 1.49 2.26
7976 BRD-A84481105 HT29 10 uM 6 h 0.0 0.0 0.0 0.25 0.88 0.18
9318 BRD-A84481105 AGS 10 uM 6 h 0.0 0.0 0.0 -0.38 -1.28 1.45
9621 BRD-A84481105 H1299 10 uM 6 h 0.23 0.98 0.09 0.0 0.0 0.0
10424 BRD-A84481105 HCT116 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
10696 BRD-A84481105 HEPG2 10 uM 6 h -0.22 -0.91 0.05 0.3 1.07 0.61
11373 BRD-A84481105 NCIH2073 10 uM 6 h 0.0 0.0 0.0 0.36 1.27 1.34
11678 BRD-A84481105 NCIH508 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
11943 BRD-A84481105 NCIH596 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
12692 BRD-A84481105 SW480 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
13009 BRD-A84481105 THP1 10 uM 6 h -0.19 -0.8 0.0 0.32 1.14 0.87
13171 BRD-A84481105 U937 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
50127 BRD-A84481105 HA1E 10 uM 6 h -0.21 -0.88 0.03 0.0 0.0 0.0
60672 BRD-A84481105 VCAP 10 uM 6 h 0.0 0.0 0.0 0.23 0.81 0.09
90538 BRD-A84481105 A549 10 uM 6 h 0.0 0.0 0.0 0.37 1.31 1.59
109154 BRD-A84481105 U2OS 20 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
125647 BRD-A84481105 HEK293 10 uM 24 h 0.24 1.01 0.12 0.28 1.0 0.42
125673 BRD-A84481105 HELA 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
125727 BRD-A84481105 HUVEC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
125773 BRD-A84481105 JURKAT 0.04 uM 24 h -0.2 -0.85 0.01 0.21 0.73 0.03
125848 BRD-A84481105 MDAMB231 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
125926 BRD-A84481105 YAPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
133851 BRD-A84481105 MCF10A 2.22 uM 24 h -0.24 -1.01 0.17 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).