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CMap Candidate Details

Structure:
CMap ID: C05418
Pert ID: BRD-A82522119
Compound Name: tibolone
Targets: ESR1
MoA: androgen receptor agonist; estrogen receptor agonist; progesterone receptor agonist
SMILES: C[C@@H]1CC2=C(CCC(=O)C2)[C@H]2CC[C@@]3(C)[C@H](CC[C@@]3(O)C#C)C12
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
127363 BRD-A82522119 A375 0.37 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
127399 BRD-A82522119 A549 0.37 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
127437 BRD-A82522119 HA1E 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
127488 BRD-A82522119 HT29 0.125 uM 24 h 0.0 0.0 0.0 -0.27 -0.92 0.33
127528 BRD-A82522119 JURKAT 0.37 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
127561 BRD-A82522119 MCF10A 0.125 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
127579 BRD-A82522119 MCF??7.00 0.125 uM 24 h 0.29 1.22 0.48 -0.3 -1.02 0.59
127618 BRD-A82522119 PC3 10 uM 24 h 0.0 0.0 0.0 -0.26 -0.86 0.22
127654 BRD-A82522119 THP1 1.11 uM 24 h 0.18 0.75 0.0 0.0 0.0 0.0
127699 BRD-A82522119 YAPC 0.125 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
135375 BRD-A82522119 HELA 0.08 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).