CKDkb: a knowledge base and platform for drug development against non-alcoholic fatty liver disease

Structure:

CMap ID:	C05432
Pert ID:	BRD-A64406146
Compound Name:	timofibrate
Targets:	LPL
MoA:	cholesterol inhibitor; lipase clearing factor inhibitor
SMILES:	CC(C)(Oc1ccc(Cl)cc1)C(=O)N1CSCC1C(O)=O
InchiKey:
Compound Aliases:

The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).
Score ID	Pert ID	Cell Line	Pert Dose	Pert Time	Raw Score (GSE126848)	Normalized Score (GSE126848)	fdr_q_nlog10 (GSE126848)	Raw Score (GSE135251)	Normalized Score (GSE135251)	fdr_q_nlog10 (GSE135251)
124969	BRD-A64406146	A549	10 uM	24 h	-0.26	-1.09	0.32	0.0	0.0	0.0
125001	BRD-A64406146	HA1E	3.33 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
125077	BRD-A64406146	MCF10A	3.33 uM	24 h	-0.23	-0.94	0.08	-0.26	-0.87	0.23
125114	BRD-A64406146	MDAMB231	0.37 uM	24 h	-0.32	-1.34	0.98	0.0	0.0	0.0
125167	BRD-A64406146	THP1	3.33 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
125210	BRD-A64406146	YAPC	0.125 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
132980	BRD-A64406146	A375	0.74 uM	24 h	0.0	0.0	0.0	0.27	0.95	0.32
133054	BRD-A64406146	HEK293	0.01 uM	24 h	0.0	0.0	0.0	0.33	1.17	0.93
133091	BRD-A64406146	HELA	0.03 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
133119	BRD-A64406146	HT29	0.01 uM	24 h	0.28	1.17	0.36	0.0	0.0	0.0
133161	BRD-A64406146	JURKAT	0.74 uM	24 h	0.21	0.86	0.01	0.0	0.0	0.0
133228	BRD-A64406146	MCF??7.00	2.22 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
133294	BRD-A64406146	PC3	0.01 uM	24 h	0.25	1.06	0.19	-0.25	-0.84	0.18

Summary