CKDkb: a knowledge base and platform for drug development against non-alcoholic fatty liver disease

Structure:

CMap ID:	C05442
Pert ID:	BRD-K62965247
Compound Name:	tipifarnib
Targets:	FNTA\|FNTB
MoA:	farnesyltransferase inhibitor
SMILES:	Cn1cncc1[C@@](N)(c1ccc(Cl)cc1)c1ccc2n(C)c(=O)cc(-c3cccc(Cl)c3)c2c1
InchiKey:
Compound Aliases:

The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).
Score ID	Pert ID	Cell Line	Pert Dose	Pert Time	Raw Score (GSE126848)	Normalized Score (GSE126848)	fdr_q_nlog10 (GSE126848)	Raw Score (GSE135251)	Normalized Score (GSE135251)	fdr_q_nlog10 (GSE135251)
9109	BRD-K62965247	A549	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
9468	BRD-K62965247	AGS	10 uM	6 h	0.0	0.0	0.0	0.33	1.18	0.98
9775	BRD-K62965247	H1299	10 uM	6 h	0.0	0.0	0.0	0.0	0.0	0.0
10234	BRD-K62965247	HCC515	10 uM	24 h	-0.29	-1.2	0.55	0.0	0.0	0.0
10558	BRD-K62965247	HCT116	10 uM	6 h	0.0	0.0	0.0	0.21	0.75	0.04
10817	BRD-K62965247	HEPG2	10 uM	6 h	0.24	0.99	0.1	0.45	1.58	2.35
11534	BRD-K62965247	NCIH2073	10 uM	6 h	0.0	0.0	0.0	-0.29	-0.98	0.48
11802	BRD-K62965247	NCIH508	10 uM	6 h	0.0	0.0	0.0	-0.4	-1.33	1.74
12096	BRD-K62965247	NCIH596	10 uM	6 h	0.0	0.0	0.0	0.0	0.0	0.0
12833	BRD-K62965247	SW480	10 uM	6 h	0.0	0.0	0.0	-0.23	-0.78	0.09
13320	BRD-K62965247	U937	10 uM	6 h	0.0	0.0	0.0	0.0	0.0	0.0
13490	BRD-K62965247	VCAP	10 uM	24 h	-0.29	-1.19	0.55	0.0	0.0	0.0
124575	BRD-K62965247	A375	10 uM	24 h	0.0	0.0	0.0	0.32	1.14	0.86
124612	BRD-K62965247	HA1E	0.37 uM	24 h	0.2	0.85	0.01	0.0	0.0	0.0
124637	BRD-K62965247	HEK293	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
124688	BRD-K62965247	HT29	3.33 uM	24 h	0.0	0.0	0.0	0.39	1.38	2.16
124741	BRD-K62965247	MCF10A	3.33 uM	24 h	0.21	0.87	0.01	0.26	0.93	0.27
124757	BRD-K62965247	MCF??7.00	3.33 uM	24 h	-0.18	-0.75	0.0	0.0	0.0	0.0
124791	BRD-K62965247	MDAMB231	10 uM	24 h	0.25	1.06	0.18	0.35	1.24	1.24
124832	BRD-K62965247	PC3	10 uM	24 h	0.0	0.0	0.0	-0.28	-0.94	0.39
124874	BRD-K62965247	THP1	10 uM	24 h	0.33	1.36	0.97	0.0	0.0	0.0
132785	BRD-K62965247	HELA	0.03 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
132830	BRD-K62965247	JURKAT	2.22 uM	24 h	0.0	0.0	0.0	0.28	0.98	0.37
132948	BRD-K62965247	YAPC	2.22 uM	24 h	-0.27	-1.12	0.38	0.0	0.0	0.0

Summary