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CMap Candidate Details

Structure:
CMap ID: C05454
Pert ID: BRD-K33379087
Compound Name: tivantinib
Targets: MET
MoA: tyrosine kinase inhibitor
SMILES: O=C1NC(=O)[C@H]([C@@H]1c1c[nH]c2ccccc12)c1cn2CCCc3cccc1c23
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
91800 BRD-K33379087 HS578T 10 uM 6 h 0.3 1.23 0.5 -0.31 -1.03 0.64
91932 BRD-K33379087 SKBR3 2.22 uM 24 h 0.0 0.0 0.0 -0.42 -1.42 2.19
92888 BRD-K33379087 A549 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
92916 BRD-K33379087 ASC 3.33 uM 24 h 0.22 0.94 0.05 -0.35 -1.19 1.15
92973 BRD-K33379087 CD34 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
93030 BRD-K33379087 HA1E 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
93066 BRD-K33379087 HEK293 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
93153 BRD-K33379087 HEPG2 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
93200 BRD-K33379087 HUVEC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
93256 BRD-K33379087 JURKAT 0.12 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
93303 BRD-K33379087 MCF10A 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
93343 BRD-K33379087 MDAMB231 10 uM 24 h 0.0 0.0 0.0 -0.36 -1.21 1.24
93384 BRD-K33379087 NPC 0.12 uM 24 h 0.0 0.0 0.0 -0.37 -1.24 1.31
93470 BRD-K33379087 SKL 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
93529 BRD-K33379087 THP1 3.33 uM 24 h 0.22 0.92 0.04 0.0 0.0 0.0
117008 BRD-K33379087 A375 0.37 uM 24 h 0.2 0.83 0.0 0.0 0.0 0.0
117124 BRD-K33379087 HCC515 10 uM 24 h 0.0 0.0 0.0 0.36 1.27 1.34
120660 BRD-K33379087 HT29 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
120821 BRD-K33379087 YAPC 1.11 uM 24 h 0.0 0.0 0.0 -0.4 -1.33 1.84
129036 BRD-K33379087 HELA 2.22 uM 3 h 0.0 0.0 0.0 -0.46 -1.55 15.35
129054 BRD-K33379087 MCF??7.00 2.22 uM 24 h 0.0 0.0 0.0 0.3 1.06 0.6
129080 BRD-K33379087 PC3 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).