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CMap Candidate Details

Structure:
CMap ID: C05478
Pert ID: BRD-K82562631
Compound Name: tolmetin
Targets: PTGS1|PTGS2
MoA: cyclooxygenase inhibitor
SMILES: Cc1ccc(cc1)C(=O)c1ccc(CC(O)=O)n1C
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
5232 BRD-K82562631 A375 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
5369 BRD-K82562631 HA1E 10 uM 24 h 0.2 0.85 0.01 0.36 1.28 1.37
5689 BRD-K82562631 HCC515 10 uM 24 h -0.2 -0.85 0.01 -0.35 -1.16 1.11
5959 BRD-K82562631 HEPG2 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
6221 BRD-K82562631 PC3 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
6423 BRD-K82562631 VCAP 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
37415 BRD-K82562631 A549 10 uM 6 h 0.0 0.0 0.0 -0.21 -0.72 0.04
37748 BRD-K82562631 ASC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
38111 BRD-K82562631 HT29 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
38563 BRD-K82562631 NPC 10 uM 24 h 0.0 0.0 0.0 0.33 1.17 0.92
38783 BRD-K82562631 PHH 10 uM 24 h -0.18 -0.75 0.0 0.0 0.0 0.0
39013 BRD-K82562631 SKB 10 uM 24 h -0.23 -0.94 0.08 0.0 0.0 0.0
52043 BRD-K82562631 MCF??7.00 10 uM 24 h 0.21 0.86 0.01 0.27 0.96 0.33
91251 BRD-K82562631 HUH7 12.5 uM 72 h 0.0 0.0 0.0 -0.26 -0.88 0.25
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).