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CMap Candidate Details

Structure:
CMap ID: C05479
Pert ID: BRD-K44273375
Compound Name: tolnaftate
Targets:
MoA: fungal squalene epoxidase inhibitor
SMILES: CN(C(=S)Oc1ccc2ccccc2c1)c1cccc(C)c1
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
99549 BRD-K44273375 U2OS 6.66 uM 6 h 0.0 0.0 0.0 -0.22 -0.75 0.06
123254 BRD-K44273375 A375 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
123298 BRD-K44273375 HEK293 0.125 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
123327 BRD-K44273375 HELA 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
123377 BRD-K44273375 MCF10A 0.37 uM 24 h 0.0 0.0 0.0 0.3 1.08 0.65
123475 BRD-K44273375 THP1 10 uM 24 h -0.28 -1.18 0.51 0.24 0.85 0.14
131569 BRD-K44273375 A549 2.22 uM 24 h 0.0 0.0 0.0 -0.4 -1.33 1.82
131604 BRD-K44273375 HA1E 0.08 uM 24 h 0.25 1.06 0.18 0.0 0.0 0.0
131697 BRD-K44273375 HT29 0.01 uM 24 h 0.0 0.0 0.0 0.25 0.89 0.2
131750 BRD-K44273375 HUVEC 0.08 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
131806 BRD-K44273375 JURKAT 2.22 uM 24 h -0.24 -1.0 0.14 0.31 1.08 0.66
131877 BRD-K44273375 MCF??7.00 0.74 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
131909 BRD-K44273375 MDAMB231 0.03 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
131922 BRD-K44273375 PC3 0.25 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
131964 BRD-K44273375 YAPC 2.22 uM 24 h -0.28 -1.15 0.44 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).