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CMap Candidate Details

Structure:
CMap ID: C05488
Pert ID: BRD-K74765201
Compound Name: tomelukast
Targets: CYSLTR1
MoA: leukotriene receptor antagonist
SMILES: CCCc1c(OCCCCc2nnn[nH]2)ccc(C(C)=O)c1O
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
25187 BRD-K74765201 PC3 10 uM 24 h 0.0 0.0 0.0 -0.23 -0.79 0.1
25419 BRD-K74765201 VCAP 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
98768 BRD-K74765201 NPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
98931 BRD-K74765201 NEU 10 uM 24 h 0.2 0.82 0.0 0.34 1.21 1.15
127094 BRD-K74765201 HELA 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
127135 BRD-K74765201 HT29 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
127162 BRD-K74765201 JURKAT 0.01 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
127277 BRD-K74765201 THP1 1.11 uM 24 h -0.24 -1.02 0.17 0.0 0.0 0.0
135015 BRD-K74765201 A375 0.001 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
135039 BRD-K74765201 A549 0.01 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
135081 BRD-K74765201 HA1E 0.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
135105 BRD-K74765201 HEK293 0.22 uM 24 h 0.28 1.18 0.4 0.0 0.0 0.0
135202 BRD-K74765201 MCF10A 0.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
135228 BRD-K74765201 MCF??7.00 0.08 uM 24 h 0.0 0.0 0.0 0.37 1.3 1.59
135258 BRD-K74765201 MDAMB231 0.22 uM 24 h 0.0 0.0 0.0 0.24 0.85 0.14
135326 BRD-K74765201 YAPC 0.003 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).