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CMap Candidate Details

Structure:
CMap ID: C05497
Pert ID: BRD-K40175214
Compound Name: torin-1
Targets: MTOR
MoA: mTOR inhibitor
SMILES: CCC(=O)N1CCN(CC1)c1ccc(cc1C(F)(F)F)-n1c2c(ccc1=O)cnc1ccc(cc21)-c1cnc2ccccc2c1
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
33807 BRD-K40175214 A549 10 uM 24 h 0.0 0.0 0.0 -0.3 -1.02 0.61
34100 BRD-K40175214 ASC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
34617 BRD-K40175214 HCC515 10 uM 6 h 0.0 0.0 0.0 -0.29 -0.97 0.45
34883 BRD-K40175214 HEPG2 10 uM 6 h 0.0 0.0 0.0 -0.28 -0.94 0.37
35567 BRD-K40175214 NEU 10 uM 24 h 0.0 0.0 0.0 0.23 0.83 0.12
35781 BRD-K40175214 NPC 10 uM 24 h 0.0 0.0 0.0 -0.32 -1.09 0.82
36082 BRD-K40175214 PC3 10 uM 6 h 0.0 0.0 0.0 -0.34 -1.13 1.01
36262 BRD-K40175214 PHH 10 uM 24 h -0.25 -1.04 0.22 -0.25 -0.83 0.16
36559 BRD-K40175214 SKB 10 uM 24 h 0.0 0.0 0.0 -0.19 -0.63 0.0
36966 BRD-K40175214 VCAP 10 uM 6 h 0.28 1.15 0.34 0.0 0.0 0.0
90449 BRD-K40175214 HL60 0.2 uM 2 h 0.0 0.0 0.0 0.24 0.87 0.17
92483 BRD-K40175214 BT20 10 uM 24 h 0.0 0.0 0.0 -0.27 -0.91 0.31
92514 BRD-K40175214 HA1E 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
92570 BRD-K40175214 HME1 10 uM 3 h 0.29 1.21 0.45 0.0 0.0 0.0
92614 BRD-K40175214 HS578T 10 uM 3 h 0.23 0.97 0.08 -0.29 -0.97 0.46
92687 BRD-K40175214 LNCAP 10 uM 24 h 0.0 0.0 0.0 -0.28 -0.94 0.37
92753 BRD-K40175214 MCF10A 0.12 uM 3 h -0.39 -1.61 15.35 -0.27 -0.91 0.3
92763 BRD-K40175214 MCF??7.00 10 uM 3 h 0.25 1.05 0.17 0.0 0.0 0.0
92781 BRD-K40175214 MDAMB231 10 uM 24 h 0.0 0.0 0.0 -0.29 -0.97 0.46
92855 BRD-K40175214 SKBR3 10 uM 3 h 0.24 1.0 0.11 -0.24 -0.79 0.11
97316 BRD-K40175214 HAP1 0.66 uM 24 h 0.22 0.92 0.04 0.28 0.98 0.37
119717 BRD-K40175214 JURKAT 10 uM 24 h 0.0 0.0 0.0 -0.16 -0.54 0.0
129589 BRD-K40175214 A375 0.25 uM 24 h 0.29 1.21 0.46 -0.3 -1.0 0.52
129616 BRD-K40175214 HELA 2.22 uM 24 h 0.0 0.0 0.0 -0.41 -1.38 2.02
129646 BRD-K40175214 HT29 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
129742 BRD-K40175214 YAPC 0.25 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).