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CMap Candidate Details

Structure:
CMap ID: C05498
Pert ID: BRD-K68174511
Compound Name: torin-2
Targets: MTOR
MoA: mTOR inhibitor
SMILES: Nc1ccc(cn1)-c1ccc2ncc3ccc(=O)n(-c4cccc(c4)C(F)(F)F)c3c2c1
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
33920 BRD-K68174511 A549 10 uM 6 h 0.0 0.0 0.0 -0.24 -0.79 0.11
34158 BRD-K68174511 ASC 10 uM 24 h 0.21 0.88 0.01 -0.26 -0.88 0.26
34405 BRD-K68174511 HA1E 10 uM 6 h 0.0 0.0 0.0 -0.27 -0.9 0.28
34938 BRD-K68174511 HEPG2 10 uM 6 h 0.33 1.36 0.97 -0.33 -1.09 0.84
35186 BRD-K68174511 HT29 10 uM 6 h 0.0 0.0 0.0 -0.17 -0.57 0.0
35988 BRD-K68174511 PC3 10 uM 24 h 0.0 0.0 0.0 0.27 0.97 0.35
36323 BRD-K68174511 PHH 10 uM 24 h 0.0 0.0 0.0 -0.31 -1.03 0.64
36621 BRD-K68174511 SKB 10 uM 24 h 0.0 0.0 0.0 -0.32 -1.08 0.79
36992 BRD-K68174511 VCAP 10 uM 6 h 0.0 0.0 0.0 -0.27 -0.9 0.29
91608 BRD-K68174511 HS578T 10 uM 6 h 0.35 1.47 1.12 -0.21 -0.71 0.03
91995 BRD-K68174511 A375 1.11 uM 24 h 0.31 1.3 0.72 -0.2 -0.67 0.02
92041 BRD-K68174511 BT20 10 uM 3 h 0.27 1.13 0.29 0.0 0.0 0.0
92105 BRD-K68174511 HCC515 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
92236 BRD-K68174511 MCF10A 1.11 uM 3 h 0.0 0.0 0.0 0.0 0.0 0.0
92273 BRD-K68174511 MCF??7.00 10 uM 3 h 0.35 1.46 1.12 -0.3 -0.99 0.51
92313 BRD-K68174511 MDAMB231 10 uM 3 h 0.31 1.31 0.76 0.0 0.0 0.0
92390 BRD-K68174511 SKBR3 0.04 uM 3 h 0.0 0.0 0.0 -0.32 -1.09 0.84
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).