CKDkb: a knowledge base and platform for drug development against non-alcoholic fatty liver disease

Structure:

CMap ID:	C05511
Pert ID:	BRD-K51033547
Compound Name:	tramadol
Targets:	CHRFAM7A\|CHRM3\|GRIN3A\|HTR2C\|OPRD1\|OPRK1\|OPRM1\|SLC6A2\|SLC6A4
MoA:	norepinephrine reputake inhibitor; opioid receptor agonist; serotonin reuptake inhibitor
SMILES:	COc1cccc(c1)[C@]1(O)CCCC[C@H]1CN(C)C
InchiKey:
Compound Aliases:

The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).
Score ID	Pert ID	Cell Line	Pert Dose	Pert Time	Raw Score (GSE126848)	Normalized Score (GSE126848)	fdr_q_nlog10 (GSE126848)	Raw Score (GSE135251)	Normalized Score (GSE135251)	fdr_q_nlog10 (GSE135251)
4441	BRD-K51033547	HCC515	10 uM	24 h	0.0	0.0	0.0	-0.26	-0.88	0.25
4935	BRD-K51033547	VCAP	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
37395	BRD-K51033547	A549	10 uM	6 h	0.0	0.0	0.0	0.0	0.0	0.0
37682	BRD-K51033547	ASC	10 uM	24 h	0.0	0.0	0.0	-0.3	-1.01	0.58
37917	BRD-K51033547	HEPG2	10 uM	6 h	0.0	0.0	0.0	0.0	0.0	0.0
38740	BRD-K51033547	PHH	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
38967	BRD-K51033547	SKB	10 uM	24 h	0.21	0.86	0.01	0.0	0.0	0.0
121622	BRD-K51033547	HA1E	1.11 uM	24 h	0.0	0.0	0.0	0.32	1.13	0.82
121692	BRD-K51033547	MCF??7.00	0.125 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
129590	BRD-K51033547	A375	0.08 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
129617	BRD-K51033547	HELA	0.01 uM	24 h	-0.37	-1.56	1.43	0.0	0.0	0.0
129647	BRD-K51033547	HT29	2.22 uM	24 h	0.3	1.24	0.53	-0.38	-1.27	1.4
129709	BRD-K51033547	PC3	0.08 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
129743	BRD-K51033547	YAPC	0.03 uM	24 h	-0.18	-0.76	0.0	0.0	0.0	0.0

Summary