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CMap Candidate Details

Structure:
CMap ID: C05512
Pert ID: BRD-K12343256
Compound Name: trametinib
Targets: MAP2K1|MAP2K2
MoA: MEK inhibitor
SMILES: CC(=O)Nc1cccc(c1)-n1c2c(C)c(=O)n(C)c(Nc3ccc(I)cc3F)c2c(=O)n(C2CC2)c1=O
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
40 BRD-K12343256 BJAB 0.04 uM 4 h -0.2 -0.84 0.01 0.24 0.85 0.15
78 BRD-K12343256 HBL1 2.5 uM 24 h -0.19 -0.79 0.0 0.0 0.0 0.0
118 BRD-K12343256 K562 0.01 uM 24 h -0.22 -0.92 0.06 0.0 0.0 0.0
161 BRD-K12343256 KMS34 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
204 BRD-K12343256 NALM6 0.01 uM 24 h 0.0 0.0 0.0 0.33 1.17 0.95
242 BRD-K12343256 OCILY10 0.66 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
302 BRD-K12343256 OCILY19 0.66 uM 4 h 0.29 1.21 0.47 0.23 0.83 0.12
348 BRD-K12343256 OCILY3 10 uM 4 h 0.0 0.0 0.0 -0.34 -1.14 1.02
360 BRD-K12343256 SKMEL5 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
414 BRD-K12343256 THP1 2.5 uM 4 h 0.0 0.0 0.0 0.0 0.0 0.0
455 BRD-K12343256 TMD8 0.66 uM 4 h 0.0 0.0 0.0 0.0 0.0 0.0
1260 BRD-K12343256 A549 0.12 uM 48 h -0.22 -0.92 0.06 0.0 0.0 0.0
1405 BRD-K12343256 U2OS 10 uM 6 h 0.21 0.88 0.01 0.38 1.36 1.72
92052 BRD-K12343256 BT20 10 uM 3 h 0.0 0.0 0.0 0.0 0.0 0.0
92121 BRD-K12343256 HCC515 10 uM 24 h 0.0 0.0 0.0 0.25 0.89 0.2
92174 BRD-K12343256 HS578T 0.04 uM 3 h 0.0 0.0 0.0 0.0 0.0 0.0
92246 BRD-K12343256 MCF10A 10 uM 3 h 0.0 0.0 0.0 0.46 1.63 2.42
92325 BRD-K12343256 MDAMB231 0.12 uM 3 h 0.0 0.0 0.0 0.0 0.0 0.0
92382 BRD-K12343256 SKBR3 10 uM 24 h 0.0 0.0 0.0 0.28 1.0 0.42
97296 BRD-K12343256 HAP1 0.66 uM 24 h 0.25 1.04 0.14 0.0 0.0 0.0
116989 BRD-K12343256 A375 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
117070 BRD-K12343256 HA1E 10 uM 24 h 0.0 0.0 0.0 0.33 1.16 0.9
117153 BRD-K12343256 HEPG2 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
117198 BRD-K12343256 HT29 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
117242 BRD-K12343256 MCF??7.00 0.125 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
117280 BRD-K12343256 PC3 10 uM 24 h -0.24 -1.01 0.16 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).