CKDkb: a knowledge base and platform for drug development against non-alcoholic fatty liver disease

Structure:

CMap ID:	C05527
Pert ID:	BRD-K70778732
Compound Name:	trazodone
Targets:	ADRA1A\|ADRA2A\|HRH1\|HTR1A\|HTR2A\|HTR2B\|HTR2C\|SLC6A4
MoA:	adrenergic receptor antagonist; serotonin receptor antagonist; serotonin reuptake inhibitor
SMILES:	Clc1cccc(c1)N1CCN(CCCn2nc3ccccn3c2=O)CC1
InchiKey:
Compound Aliases:

The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).
Score ID	Pert ID	Cell Line	Pert Dose	Pert Time	Raw Score (GSE126848)	Normalized Score (GSE126848)	fdr_q_nlog10 (GSE126848)	Raw Score (GSE135251)	Normalized Score (GSE135251)	fdr_q_nlog10 (GSE135251)
5678	BRD-K70778732	HCC515	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
5950	BRD-K70778732	HEPG2	10 uM	6 h	0.0	0.0	0.0	0.0	0.0	0.0
25530	BRD-K70778732	VCAP	10 uM	6 h	0.0	0.0	0.0	-0.27	-0.92	0.33
39753	BRD-K70778732	ASC	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
40856	BRD-K70778732	NEU	10 uM	24 h	0.0	0.0	0.0	-0.25	-0.83	0.16
41171	BRD-K70778732	NPC	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
41509	BRD-K70778732	SKB	10 uM	24 h	-0.24	-0.99	0.13	0.0	0.0	0.0
99407	BRD-K70778732	U2OS	10 uM	6 h	0.0	0.0	0.0	0.34	1.19	1.01
126378	BRD-K70778732	A549	0.37 uM	24 h	0.0	0.0	0.0	0.28	0.98	0.37
126431	BRD-K70778732	HEK293	0.04 uM	24 h	0.0	0.0	0.0	-0.29	-0.97	0.46
126473	BRD-K70778732	HELA	1.11 uM	24 h	-0.25	-1.05	0.23	0.22	0.78	0.06
126519	BRD-K70778732	MCF10A	3.33 uM	24 h	-0.24	-0.99	0.13	-0.25	-0.83	0.17
126535	BRD-K70778732	MCF??7.00	3.33 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
126553	BRD-K70778732	MDAMB231	0.04 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
134343	BRD-K70778732	A375	0.74 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
134396	BRD-K70778732	HA1E	0.03 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
134459	BRD-K70778732	HT29	0.01 uM	24 h	0.0	0.0	0.0	0.31	1.11	0.71
134497	BRD-K70778732	HUVEC	0.25 uM	24 h	0.0	0.0	0.0	-0.31	-1.03	0.65
134621	BRD-K70778732	PC3	2.22 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
134650	BRD-K70778732	YAPC	0.25 uM	24 h	0.0	0.0	0.0	-0.29	-0.99	0.5

Summary