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CMap Candidate Details

Structure:
CMap ID: C05533
Pert ID: BRD-K84663978
Compound Name: trequinsin
Targets: PDE5A
MoA: phosphodiesterase inhibitor
SMILES: COc1cc2CCn3c(c\c(=N/c4c(C)cc(C)cc4C)n(C)c3=O)-c2cc1OC
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
6806 BRD-K84663978 A375 10 uM 24 h 0.0 0.0 0.0 -0.3 -1.02 0.61
7486 BRD-K84663978 HA1E 10 uM 6 h -0.2 -0.82 0.0 0.0 0.0 0.0
7722 BRD-K84663978 HCC515 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
8028 BRD-K84663978 HT29 10 uM 6 h -0.22 -0.93 0.07 0.0 0.0 0.0
8728 BRD-K84663978 VCAP 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
91383 BRD-K84663978 HUH7 8 uM 72 h 0.0 0.0 0.0 0.27 0.96 0.34
96891 BRD-K84663978 PC3 10 uM 24 h -0.21 -0.87 0.02 0.0 0.0 0.0
119447 BRD-K84663978 A549 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
119551 BRD-K84663978 HEPG2 0.12 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
119612 BRD-K84663978 MCF??7.00 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).