Logo 1 Logo 2

CMap Candidate Details

Structure:
CMap ID: C05553
Pert ID: BRD-K81916719
Compound Name: triclabendazole
Targets: DNMT1
MoA: microtubule inhibitor
SMILES: CSc1nc2cc(Cl)c(Oc3cccc(Cl)c3Cl)cc2[nH]1
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
25425 BRD-K81916719 VCAP 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
125980 BRD-K81916719 A549 3.33 uM 24 h 0.23 0.95 0.07 0.22 0.79 0.07
126000 BRD-K81916719 HA1E 10 uM 24 h 0.0 0.0 0.0 -0.34 -1.16 1.11
126027 BRD-K81916719 HELA 10 uM 24 h 0.0 0.0 0.0 -0.25 -0.84 0.18
126048 BRD-K81916719 HT29 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
126074 BRD-K81916719 HUVEC 0.37 uM 24 h 0.0 0.0 0.0 -0.3 -1.02 0.62
126118 BRD-K81916719 JURKAT 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
126171 BRD-K81916719 MCF10A 0.37 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
126235 BRD-K81916719 MDAMB231 10 uM 24 h 0.0 0.0 0.0 -0.28 -0.96 0.42
126290 BRD-K81916719 THP1 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
126336 BRD-K81916719 YAPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
134000 BRD-K81916719 A375 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
134092 BRD-K81916719 HEK293 0.01 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
134223 BRD-K81916719 MCF??7.00 0.74 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
134284 BRD-K81916719 PC3 0.74 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).