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CMap Candidate Details

Structure:
CMap ID: C05571
Pert ID: BRD-K07208025
Compound Name: trimethoprim
Targets: DHFR|TYMS
MoA: dihydrofolate reductase inhibitor
SMILES: COc1cc(Cc2cnc(N)nc2N)cc(OC)c1OC
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
91257 BRD-K07208025 HUH7 12 uM 72 h 0.0 0.0 0.0 0.0 0.0 0.0
100019 BRD-K07208025 U2OS 10 uM 6 h 0.22 0.9 0.03 0.0 0.0 0.0
122552 BRD-K07208025 A375 0.04 uM 24 h 0.21 0.87 0.01 0.0 0.0 0.0
122582 BRD-K07208025 A549 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
122604 BRD-K07208025 HA1E 10 uM 24 h 0.23 0.97 0.08 0.0 0.0 0.0
122730 BRD-K07208025 MCF10A 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
122798 BRD-K07208025 PC3 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
122818 BRD-K07208025 YAPC 1.11 uM 24 h 0.3 1.25 0.54 0.21 0.75 0.04
130940 BRD-K07208025 HEK293 0.03 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
130973 BRD-K07208025 HELA 0.03 uM 24 h 0.17 0.7 0.0 0.0 0.0 0.0
131004 BRD-K07208025 HT29 0.03 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
131052 BRD-K07208025 HUVEC 0.01 uM 24 h 0.0 0.0 0.0 0.28 0.98 0.39
131088 BRD-K07208025 MCF??7.00 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
131125 BRD-K07208025 MDAMB231 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).