CKDkb: a knowledge base and platform for drug development against non-alcoholic fatty liver disease

Structure:

CMap ID:	C05575
Pert ID:	BRD-A19195498
Compound Name:	trimipramine
Targets:	ADRA1A\|ADRA1B\|ADRA2A\|ADRA2B\|ADRB1\|ADRB2\|ADRB3\|CHRM1\|CHRM2\|CHRM3\|CHRM4\|CHRM5\|DRD1\|DRD2\|DRD5\|HRH1\|HTR1A\|HTR1D\|HTR2A\|HTR2C\|HTR3A\|SLC6A2\|SLC6A3\|SLC6A4
MoA:	norepinephrine reputake inhibitor; tricyclic antidepressant
SMILES:	CC(CN(C)C)CN1c2ccccc2CCc2ccccc12
InchiKey:
Compound Aliases:

The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).
Score ID	Pert ID	Cell Line	Pert Dose	Pert Time	Raw Score (GSE126848)	Normalized Score (GSE126848)	fdr_q_nlog10 (GSE126848)	Raw Score (GSE135251)	Normalized Score (GSE135251)	fdr_q_nlog10 (GSE135251)
5390	BRD-A19195498	HA1E	10 uM	6 h	0.24	1.0	0.11	0.0	0.0	0.0
5504	BRD-A19195498	HCC515	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
6453	BRD-A19195498	VCAP	10 uM	6 h	0.0	0.0	0.0	0.0	0.0	0.0
39390	BRD-A19195498	A549	10 uM	6 h	0.0	0.0	0.0	-0.28	-0.96	0.43
39552	BRD-A19195498	ASC	10 uM	24 h	0.0	0.0	0.0	0.36	1.29	1.49
39882	BRD-A19195498	HEPG2	10 uM	6 h	0.0	0.0	0.0	0.32	1.14	0.87
40684	BRD-A19195498	NEU	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
40978	BRD-A19195498	NPC	10 uM	24 h	0.0	0.0	0.0	-0.3	-1.02	0.61
41301	BRD-A19195498	SKB	10 uM	24 h	-0.24	-0.98	0.13	0.25	0.88	0.18
96444	BRD-A19195498	A375	10 uM	24 h	-0.16	-0.67	0.0	0.0	0.0	0.0
96512	BRD-A19195498	PC3	1.11 uM	24 h	0.0	0.0	0.0	-0.26	-0.89	0.27
120928	BRD-A19195498	HEK293	10 uM	24 h	0.22	0.9	0.02	0.0	0.0	0.0
120992	BRD-A19195498	HELA	10 uM	3 h	-0.3	-1.23	0.63	0.33	1.16	0.9
121026	BRD-A19195498	MCF??7.00	0.04 uM	24 h	0.0	0.0	0.0	-0.33	-1.11	0.92
121086	BRD-A19195498	YAPC	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
129177	BRD-A19195498	HT29	0.01 uM	24 h	-0.23	-0.96	0.1	0.26	0.91	0.23

Summary