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CMap Candidate Details

Structure:
CMap ID: C05621
Pert ID: BRD-K49657628
Compound Name: tyrphostin-AG-18
Targets: EGFR
MoA: EGFR inhibitor; tyrosine kinase inhibitor
SMILES: Oc1ccc(C=C(C#N)C#N)cc1O
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
2889 BRD-K49657628 HA1E 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
3217 BRD-K49657628 HCC515 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
3516 BRD-K49657628 PC3 10 uM 24 h 0.0 0.0 0.0 -0.29 -0.97 0.46
3965 BRD-K49657628 VCAP 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
44412 BRD-K49657628 A375 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
44715 BRD-K49657628 A549 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
44977 BRD-K49657628 ASC 10 uM 24 h -0.2 -0.84 0.01 0.0 0.0 0.0
45273 BRD-K49657628 HEPG2 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
45541 BRD-K49657628 HT29 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
45829 BRD-K49657628 MCF??7.00 10 uM 6 h -0.24 -0.99 0.13 -0.25 -0.84 0.18
46093 BRD-K49657628 NPC 10 uM 24 h 0.0 0.0 0.0 -0.34 -1.14 1.03
46410 BRD-K49657628 PHH 10 uM 24 h 0.0 0.0 0.0 -0.36 -1.2 1.17
46732 BRD-K49657628 SKB 10 uM 24 h 0.21 0.88 0.01 0.0 0.0 0.0
99606 BRD-K49657628 U2OS 10 uM 6 h 0.0 0.0 0.0 0.23 0.82 0.1
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).