CKDkb: a knowledge base and platform for drug development against non-alcoholic fatty liver disease

Structure:

CMap ID:	C05629
Pert ID:	BRD-K91701654
Compound Name:	U-0126
Targets:	AKT1\|CHEK1\|GSK3B\|LCK\|MAP2K1\|MAP2K2\|MAP2K7\|MAPK1\|MAPK11\|MAPK12\|MAPK14\|MAPK8\|PRKCA\|RAF1\|ROCK1\|RPS6KB1\|SGK1
MoA:	MEK inhibitor
SMILES:	N\C(Sc1ccccc1N)=C(C#N)/C(C#N)=C(/N)Sc1ccccc1N
InchiKey:
Compound Aliases:

The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).
Score ID	Pert ID	Cell Line	Pert Dose	Pert Time	Raw Score (GSE126848)	Normalized Score (GSE126848)	fdr_q_nlog10 (GSE126848)	Raw Score (GSE135251)	Normalized Score (GSE135251)	fdr_q_nlog10 (GSE135251)
33727	BRD-K91701654	A375	10 uM	6 h	0.0	0.0	0.0	0.36	1.27	1.34
33945	BRD-K91701654	A549	10 uM	6 h	-0.29	-1.2	0.55	0.37	1.32	1.71
34211	BRD-K91701654	ASC	10 uM	24 h	0.0	0.0	0.0	0.4	1.42	2.19
34445	BRD-K91701654	HA1E	10 uM	6 h	0.29	1.2	0.43	0.0	0.0	0.0
34715	BRD-K91701654	HCC515	10 uM	6 h	0.0	0.0	0.0	0.31	1.08	0.66
34991	BRD-K91701654	HEPG2	10 uM	6 h	0.0	0.0	0.0	-0.32	-1.07	0.75
35228	BRD-K91701654	HT29	10 uM	6 h	0.0	0.0	0.0	0.32	1.12	0.76
35357	BRD-K91701654	MCF??7.00	10 uM	24 h	0.0	0.0	0.0	-0.26	-0.88	0.24
35638	BRD-K91701654	NEU	10 uM	24 h	0.29	1.19	0.42	0.24	0.84	0.13
35866	BRD-K91701654	NPC	10 uM	24 h	0.0	0.0	0.0	-0.35	-1.17	1.12
36012	BRD-K91701654	PC3	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
36382	BRD-K91701654	PHH	10 uM	24 h	0.23	0.98	0.09	-0.22	-0.73	0.04
36683	BRD-K91701654	SKB	10 uM	24 h	0.0	0.0	0.0	0.23	0.81	0.09
36894	BRD-K91701654	VCAP	10 uM	24 h	0.19	0.79	0.0	0.0	0.0	0.0

Summary