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CMap Candidate Details

Structure:
CMap ID: C00567
Pert ID: BRD-K42436189
Compound Name: AZ20
Targets: ATR|MTOR
MoA: ATR kinase inhibitor
SMILES: C[C@@H]1COCCN1c1cc(nc(n1)-c1cccc2[nH]ccc12)C1(CC1)S(C)(=O)=O
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
93629 BRD-K42436189 A549 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
93672 BRD-K42436189 ASC 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
93737 BRD-K42436189 CD34 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
93771 BRD-K42436189 HA1E 1.11 uM 24 h 0.0 0.0 0.0 -0.28 -0.95 0.41
93811 BRD-K42436189 HCC515 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
93862 BRD-K42436189 HEK293 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
93902 BRD-K42436189 HELA 10 uM 24 h 0.0 0.0 0.0 -0.53 -1.78 15.65
93944 BRD-K42436189 HEPG2 10 uM 24 h 0.0 0.0 0.0 -0.38 -1.26 1.38
94002 BRD-K42436189 HUVEC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
94045 BRD-K42436189 JURKAT 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
94074 BRD-K42436189 MCF??7.00 10 uM 24 h 0.2 0.85 0.01 -0.32 -1.06 0.74
94125 BRD-K42436189 NEU 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
94182 BRD-K42436189 NPC 1.11 uM 24 h 0.0 0.0 0.0 -0.32 -1.09 0.81
94205 BRD-K42436189 PC3 10 uM 24 h 0.0 0.0 0.0 -0.32 -1.08 0.8
94260 BRD-K42436189 SHSY5Y 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
94311 BRD-K42436189 SKL 10 uM 24 h 0.22 0.9 0.03 -0.24 -0.82 0.15
94355 BRD-K42436189 THP1 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
94393 BRD-K42436189 YAPC 3.33 uM 24 h 0.0 0.0 0.0 -0.41 -1.4 2.02
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).