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CMap Candidate Details

Structure:
CMap ID: C05709
Pert ID: BRD-A86216746
Compound Name: varenicline
Targets: CHRNA3|CHRNA4|CHRNA6|CHRNA7
MoA: acetylcholine receptor agonist
SMILES: C1C2CNCC1c1cc3nccnc3cc21
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
125581 BRD-A86216746 A375 0.37 uM 24 h 0.0 0.0 0.0 0.32 1.14 0.87
125630 BRD-A86216746 HA1E 0.37 uM 24 h -0.27 -1.14 0.42 0.31 1.1 0.7
125651 BRD-A86216746 HEK293 1.11 uM 24 h -0.24 -0.98 0.12 -0.37 -1.25 1.35
125732 BRD-A86216746 HUVEC 3.33 uM 24 h 0.3 1.24 0.53 0.0 0.0 0.0
125873 BRD-A86216746 PC3 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
125930 BRD-A86216746 YAPC 0.125 uM 24 h 0.0 0.0 0.0 -0.28 -0.93 0.35
133665 BRD-A86216746 A549 0.74 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
133764 BRD-A86216746 HELA 2.22 uM 24 h 0.0 0.0 0.0 0.28 0.98 0.37
133797 BRD-A86216746 HT29 0.25 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
133824 BRD-A86216746 JURKAT 0.01 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
133855 BRD-A86216746 MCF10A 0.25 uM 24 h 0.0 0.0 0.0 -0.29 -0.99 0.5
133881 BRD-A86216746 MCF??7.00 0.03 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
133914 BRD-A86216746 MDAMB231 0.01 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
133978 BRD-A86216746 THP1 0.08 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).