CKDkb: a knowledge base and platform for drug development against non-alcoholic fatty liver disease

Structure:

CMap ID:	C05762
Pert ID:	BRD-K93442924
Compound Name:	vorapaxar
Targets:	F2R
MoA:	thrombin receptor antagonist
SMILES:	CCOC(=O)N[C@@H]1CC[C@@H]2[C@H](C[C@@H]3[C@@H]([C@@H](C)OC3=O)[C@H]2\C=C\c2ccc(cn2)-c2cccc(F)c2)C1
InchiKey:
Compound Aliases:

The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).
Score ID	Pert ID	Cell Line	Pert Dose	Pert Time	Raw Score (GSE126848)	Normalized Score (GSE126848)	Raw Score (GSE135251)	Normalized Score (GSE135251)	fdr_q_nlog10 (GSE135251)
117342	BRD-K93442924	A375	10 uM	24 h	0.0	0.0	0.0	0.0	0.0
117382	BRD-K93442924	A549	10 uM	24 h	0.0	0.0	0.32	1.13	0.82
117420	BRD-K93442924	HA1E	10 uM	24 h	0.18	0.76	0.0	0.0	0.0
117465	BRD-K93442924	HCC515	10 uM	24 h	0.0	0.0	0.0	0.0	0.0
117512	BRD-K93442924	HEPG2	10 uM	24 h	0.0	0.0	0.42	1.49	2.26
117556	BRD-K93442924	HT29	10 uM	24 h	0.0	0.0	0.0	0.0	0.0
117597	BRD-K93442924	MCF??7.00	10 uM	24 h	0.0	0.0	0.0	0.0	0.0
117635	BRD-K93442924	PC3	0.04 uM	24 h	0.0	0.0	0.24	0.86	0.16

Summary