CKDkb: a knowledge base and platform for drug development against non-alcoholic fatty liver disease

Structure:

CMap ID:	C05767
Pert ID:	BRD-K56291712
Compound Name:	voxtalisib
Targets:	MTOR\|PIK3CA
MoA:	mTOR inhibitor; PI3K inhibitor
SMILES:	CCn1c2nc(N)nc(C)c2cc(-c2cc[nH]n2)c1=O
InchiKey:
Compound Aliases:

The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).
Score ID	Pert ID	Cell Line	Pert Dose	Pert Time	Raw Score (GSE126848)	Normalized Score (GSE126848)	fdr_q_nlog10 (GSE126848)	Raw Score (GSE135251)	Normalized Score (GSE135251)	fdr_q_nlog10 (GSE135251)
123789	BRD-K56291712	A375	3.33 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
123829	BRD-K56291712	A549	10 uM	24 h	0.0	0.0	0.0	-0.26	-0.88	0.24
123866	BRD-K56291712	HA1E	10 uM	24 h	0.0	0.0	0.0	-0.32	-1.08	0.79
123887	BRD-K56291712	HEK293	10 uM	24 h	0.0	0.0	0.0	-0.31	-1.03	0.64
123937	BRD-K56291712	HELA	3.33 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
123986	BRD-K56291712	JURKAT	3.33 uM	24 h	0.0	0.0	0.0	-0.21	-0.71	0.03
124042	BRD-K56291712	MCF10A	10 uM	24 h	0.0	0.0	0.0	-0.22	-0.75	0.07
124089	BRD-K56291712	MCF??7.00	10 uM	24 h	0.0	0.0	0.0	-0.39	-1.3	1.67
124116	BRD-K56291712	MDAMB231	1.11 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
124169	BRD-K56291712	THP1	3.33 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
124222	BRD-K56291712	YAPC	10 uM	24 h	0.0	0.0	0.0	-0.32	-1.08	0.79
132220	BRD-K56291712	HT29	2.22 uM	24 h	0.23	0.94	0.06	0.23	0.82	0.1
132289	BRD-K56291712	PC3	2.22 uM	24 h	0.0	0.0	0.0	-0.42	-1.41	2.02

Summary