CKDkb: a knowledge base and platform for drug development against non-alcoholic fatty liver disease

Structure:

CMap ID:	C05771
Pert ID:	BRD-K81694556
Compound Name:	VTP-27999
Targets:	REN
MoA:	renin inhibitor
SMILES:	CN[C@H](CNC(=O)N1CCC[C@H](C1)[C@@H](OCCNC(=O)OC)c1cccc(Cl)c1)C[C@H]1CCCOC1
InchiKey:
Compound Aliases:

The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).
Score ID	Pert ID	Cell Line	Pert Dose	Pert Time	Raw Score (GSE126848)	Normalized Score (GSE126848)	fdr_q_nlog10 (GSE126848)	Raw Score (GSE135251)	Normalized Score (GSE135251)	fdr_q_nlog10 (GSE135251)
125961	BRD-K81694556	A375	1.11 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
125979	BRD-K81694556	A549	10 uM	24 h	0.22	0.91	0.04	0.0	0.0	0.0
126117	BRD-K81694556	JURKAT	3.33 uM	24 h	0.0	0.0	0.0	0.27	0.94	0.29
126170	BRD-K81694556	MCF10A	0.04 uM	24 h	0.21	0.86	0.01	-0.24	-0.82	0.15
126257	BRD-K81694556	PC3	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
126289	BRD-K81694556	THP1	0.04 uM	24 h	-0.23	-0.98	0.12	0.0	0.0	0.0
126335	BRD-K81694556	YAPC	1.11 uM	24 h	0.0	0.0	0.0	-0.41	-1.39	2.02
134061	BRD-K81694556	HA1E	0.01 uM	24 h	-0.27	-1.12	0.38	0.0	0.0	0.0
134091	BRD-K81694556	HEK293	0.08 uM	24 h	0.0	0.0	0.0	-0.3	-1.02	0.62
134142	BRD-K81694556	HELA	0.08 uM	24 h	0.19	0.81	0.0	0.0	0.0	0.0
134176	BRD-K81694556	HT29	0.25 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
134204	BRD-K81694556	HUVEC	2.22 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
134222	BRD-K81694556	MCF??7.00	2.22 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
134251	BRD-K81694556	MDAMB231	0.08 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0

Summary