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CMap Candidate Details

Structure:
CMap ID: C05791
Pert ID: BRD-K70610771
Compound Name: VX-222
Targets:
MoA: HCV inhibitor
SMILES: C[C@H]1CC[C@@H](CC1)C(=O)N([C@@H]1CC[C@H](O)CC1)c1cc(sc1C(O)=O)C#CC(C)(C)C
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
126696 BRD-K70610771 HEK293 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
126721 BRD-K70610771 HELA 0.37 uM 24 h -0.32 -1.34 0.98 0.0 0.0 0.0
126783 BRD-K70610771 JURKAT 0.125 uM 24 h 0.0 0.0 0.0 0.33 1.15 0.89
126844 BRD-K70610771 MCF??7.00 3.33 uM 24 h -0.23 -0.94 0.08 0.22 0.79 0.07
126889 BRD-K70610771 MDAMB231 0.125 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
126956 BRD-K70610771 THP1 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
134681 BRD-K70610771 A375 0.01 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
134703 BRD-K70610771 A549 0.74 uM 24 h 0.0 0.0 0.0 -0.28 -0.96 0.43
134731 BRD-K70610771 HA1E 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
134828 BRD-K70610771 HT29 0.74 uM 24 h 0.34 1.42 1.08 0.0 0.0 0.0
134870 BRD-K70610771 HUVEC 0.08 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
134929 BRD-K70610771 MCF10A 0.74 uM 24 h 0.0 0.0 0.0 -0.34 -1.14 1.05
134967 BRD-K70610771 PC3 0.03 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
134993 BRD-K70610771 YAPC 2.22 uM 24 h 0.28 1.15 0.32 -0.29 -0.97 0.46
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).