CMap Candidate Details
Structure:
| CMap ID: | C05838 |
| Pert ID: | BRD-K12762134 |
| Compound Name: | XAV-939 |
| Targets: | TNKS|TNKS2 |
| MoA: | tankyrase inhibitor |
| SMILES: | Oc1nc(nc2CCSCc12)-c1ccc(cc1)C(F)(F)F |
| InchiKey: | |
| Compound Aliases: |
| Score ID | Pert ID | Cell Line | Pert Dose | Pert Time | Raw Score (GSE126848) | Normalized Score (GSE126848) | fdr_q_nlog10 (GSE126848) | Raw Score (GSE135251) | Normalized Score (GSE135251) | fdr_q_nlog10 (GSE135251) |
|---|---|---|---|---|---|---|---|---|---|---|
| 8913 | BRD-K12762134 | A375 | 12 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.24 | 0.84 | 0.12 |
| 9366 | BRD-K12762134 | AGS | 12 uM | 6 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 9919 | BRD-K12762134 | HA1E | 12 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 10165 | BRD-K12762134 | HCC515 | 12 uM | 24 h | -0.25 | -1.04 | 0.22 | 0.0 | 0.0 | 0.0 |
| 10737 | BRD-K12762134 | HEPG2 | 12 uM | 6 h | 0.33 | 1.38 | 0.97 | -0.26 | -0.87 | 0.23 |
| 10947 | BRD-K12762134 | HT29 | 12 uM | 24 h | 0.21 | 0.88 | 0.01 | -0.28 | -0.93 | 0.35 |
| 11172 | BRD-K12762134 | MCF??7.00 | 12 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 11425 | BRD-K12762134 | NCIH2073 | 12 uM | 6 h | -0.23 | -0.95 | 0.09 | 0.31 | 1.08 | 0.66 |
| 11716 | BRD-K12762134 | NCIH508 | 12 uM | 6 h | 0.0 | 0.0 | 0.0 | -0.3 | -1.0 | 0.55 |
| 12737 | BRD-K12762134 | SW480 | 12 uM | 6 h | 0.0 | 0.0 | 0.0 | -0.31 | -1.05 | 0.7 |
| 13216 | BRD-K12762134 | U937 | 12 uM | 6 h | 0.26 | 1.09 | 0.22 | -0.23 | -0.77 | 0.08 |
| 13585 | BRD-K12762134 | VCAP | 12 uM | 6 h | 0.0 | 0.0 | 0.0 | 0.27 | 0.95 | 0.31 |
| 90554 | BRD-K12762134 | A549 | 1.25 uM | 24 h | 0.23 | 0.98 | 0.09 | 0.24 | 0.86 | 0.16 |
| 96784 | BRD-K12762134 | PC3 | 3.33 uM | 24 h | 0.0 | 0.0 | 0.0 | -0.33 | -1.12 | 0.95 |
| 98212 | BRD-K12762134 | NPC | 10 uM | 6 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 98341 | BRD-K12762134 | NEU | 10 uM | 24 h | 0.0 | 0.0 | 0.0 | -0.24 | -0.82 | 0.14 |