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CMap Candidate Details

Structure:
CMap ID: C05860
Pert ID: BRD-K42679050
Compound Name: Y-27152
Targets: KCNJ8
MoA: potassium channel activator
SMILES: CC(=O)N(OCc1ccccc1)[C@H]1[C@H](O)C(C)(C)Oc2ccc(cc12)C#N
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
5632 BRD-K42679050 HCC515 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
6414 BRD-K42679050 VCAP 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
37659 BRD-K42679050 ASC 10 uM 24 h 0.36 1.49 1.15 0.4 1.4 2.18
37904 BRD-K42679050 HEPG2 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
38484 BRD-K42679050 NPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
38723 BRD-K42679050 PHH 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
38956 BRD-K42679050 SKB 10 uM 24 h 0.0 0.0 0.0 0.25 0.9 0.22
99531 BRD-K42679050 U2OS 10 uM 6 h 0.24 1.01 0.11 0.0 0.0 0.0
123244 BRD-K42679050 A375 0.04 uM 24 h 0.3 1.27 0.58 0.0 0.0 0.0
123292 BRD-K42679050 HEK293 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
123351 BRD-K42679050 HT29 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
123371 BRD-K42679050 MCF10A 0.125 uM 24 h 0.0 0.0 0.0 -0.28 -0.96 0.42
123403 BRD-K42679050 MDAMB231 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
123431 BRD-K42679050 PC3 1.11 uM 24 h 0.0 0.0 0.0 0.32 1.13 0.82
123468 BRD-K42679050 THP1 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
123501 BRD-K42679050 YAPC 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
131558 BRD-K42679050 A549 0.08 uM 24 h 0.0 0.0 0.0 0.41 1.46 2.23
131597 BRD-K42679050 HA1E 0.03 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
131668 BRD-K42679050 HELA 0.25 uM 24 h 0.25 1.04 0.14 0.0 0.0 0.0
131738 BRD-K42679050 HUVEC 0.03 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
131792 BRD-K42679050 JURKAT 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
131867 BRD-K42679050 MCF??7.00 0.08 uM 24 h -0.18 -0.74 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).