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CMap Candidate Details

Structure:
CMap ID: C05864
Pert ID: BRD-K56751279
Compound Name: Y-39983
Targets: ROCK1|ROCK2
MoA: rho associated kinase inhibitor
SMILES: C[C@@H](N)c1ccc(cc1)C(=O)Nc1ccnc2[nH]ccc12
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
92446 BRD-K56751279 A549 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
92484 BRD-K56751279 BT20 10 uM 24 h 0.3 1.24 0.53 0.0 0.0 0.0
92516 BRD-K56751279 HA1E 0.12 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
92548 BRD-K56751279 HME1 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
92596 BRD-K56751279 HS578T 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
92643 BRD-K56751279 HT29 1.11 uM 24 h 0.27 1.13 0.3 0.0 0.0 0.0
92705 BRD-K56751279 LNCAP 1.11 uM 3 h 0.0 0.0 0.0 0.0 0.0 0.0
92718 BRD-K56751279 MCF10A 0.37 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
92782 BRD-K56751279 MDAMB231 0.37 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
92818 BRD-K56751279 PC3 3.33 uM 24 h 0.0 0.0 0.0 -0.22 -0.74 0.05
92841 BRD-K56751279 SKBR3 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
123513 BRD-K56751279 A375 10 uM 24 h 0.25 1.03 0.13 0.32 1.13 0.82
123558 BRD-K56751279 HEK293 1.11 uM 24 h 0.22 0.92 0.04 0.0 0.0 0.0
123610 BRD-K56751279 HELA 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
132072 BRD-K56751279 MCF??7.00 2.22 uM 24 h 0.31 1.31 0.76 0.0 0.0 0.0
132132 BRD-K56751279 YAPC 2.22 uM 24 h 0.0 0.0 0.0 -0.34 -1.15 1.06
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).