CMap Candidate Details
Structure:
| CMap ID: | C05880 |
| Pert ID: | BRD-K35586044 |
| Compound Name: | yohimbine |
| Targets: | ADRA2A|ADRA2B|ADRA2C|DRD2|DRD3|HTR1A|HTR1B|HTR1D|HTR1E|HTR1F|HTR2A|HTR2B|HTR2C|HTR5A|HTR7|KCNJ1|KCNJ10|KCNJ11|KCNJ12|KCNJ14|KCNJ15|KCNJ8 |
| MoA: | adrenergic receptor antagonist |
| SMILES: | COC(=O)[C@H]1[C@@H](O)CC[C@H]2CN3CCc4c([nH]c5ccccc45)[C@@H]3C[C@H]12 |
| InchiKey: | |
| Compound Aliases: |
| Score ID | Pert ID | Cell Line | Pert Dose | Pert Time | Raw Score (GSE126848) | Normalized Score (GSE126848) | fdr_q_nlog10 (GSE126848) | Raw Score (GSE135251) | Normalized Score (GSE135251) | fdr_q_nlog10 (GSE135251) |
|---|---|---|---|---|---|---|---|---|---|---|
| 7310 | BRD-K35586044 | HA1E | 10 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.28 | 0.99 | 0.39 |
| 8810 | BRD-K35586044 | VCAP | 10 uM | 6 h | 0.0 | 0.0 | 0.0 | -0.31 | -1.03 | 0.63 |
| 91023 | BRD-K35586044 | HUH7 | 10 uM | 72 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 99876 | BRD-K35586044 | U2OS | 15 uM | 6 h | 0.23 | 0.97 | 0.08 | 0.21 | 0.75 | 0.04 |
| 120572 | BRD-K35586044 | A549 | 0.04 uM | 24 h | 0.27 | 1.13 | 0.28 | 0.0 | 0.0 | 0.0 |
| 120677 | BRD-K35586044 | HT29 | 0.37 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 120730 | BRD-K35586044 | JURKAT | 1.11 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 120788 | BRD-K35586044 | PC3 | 1.11 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 120838 | BRD-K35586044 | YAPC | 1.11 uM | 24 h | 0.2 | 0.85 | 0.0 | 0.0 | 0.0 | 0.0 |
| 128992 | BRD-K35586044 | A375 | 0.74 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 129040 | BRD-K35586044 | HELA | 0.01 uM | 3 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 129065 | BRD-K35586044 | MCF??7.00 | 0.08 uM | 24 h | -0.27 | -1.13 | 0.41 | -0.33 | -1.11 | 0.92 |