CKDkb: a knowledge base and platform for drug development against non-alcoholic fatty liver disease

Structure:

CMap ID:	C05885
Pert ID:	BRD-K71289571
Compound Name:	zafirlukast
Targets:	CYSLTR1\|CYSLTR2
MoA:	leukotriene receptor antagonist
SMILES:	COc1cc(ccc1Cc1cn(C)c2ccc(NC(=O)OC3CCCC3)cc12)C(=O)NS(=O)(=O)c1ccccc1C
InchiKey:
Compound Aliases:

The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).
Score ID	Pert ID	Cell Line	Pert Dose	Pert Time	Raw Score (GSE126848)	Normalized Score (GSE126848)	fdr_q_nlog10 (GSE126848)	Raw Score (GSE135251)	Normalized Score (GSE135251)	fdr_q_nlog10 (GSE135251)
25532	BRD-K71289571	VCAP	10 uM	6 h	0.0	0.0	0.0	0.0	0.0	0.0
50400	BRD-K71289571	HCC515	10 uM	6 h	0.0	0.0	0.0	-0.27	-0.9	0.29
51626	BRD-K71289571	MCF??7.00	10 uM	24 h	0.0	0.0	0.0	-0.3	-1.0	0.54
91072	BRD-K71289571	HUH7	6.66 uM	72 h	-0.27	-1.12	0.38	0.0	0.0	0.0
126364	BRD-K71289571	A375	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
126405	BRD-K71289571	HA1E	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
126441	BRD-K71289571	HEK293	10 uM	24 h	0.26	1.06	0.19	0.0	0.0	0.0
126496	BRD-K71289571	HT29	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
126605	BRD-K71289571	YAPC	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
134377	BRD-K71289571	A549	0.01 uM	24 h	0.0	0.0	0.0	-0.38	-1.28	1.45
134430	BRD-K71289571	HELA	2.22 uM	24 h	0.0	0.0	0.0	0.33	1.16	0.9
134507	BRD-K71289571	HUVEC	0.08 uM	24 h	0.0	0.0	0.0	0.29	1.04	0.52
134541	BRD-K71289571	MCF10A	2.22 uM	24 h	0.0	0.0	0.0	0.29	1.01	0.45
134600	BRD-K71289571	MDAMB231	0.74 uM	24 h	0.0	0.0	0.0	0.2	0.71	0.02
134628	BRD-K71289571	PC3	2.22 uM	24 h	0.0	0.0	0.0	0.32	1.13	0.84

Summary