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CMap Candidate Details

Structure:
CMap ID: C05888
Pert ID: BRD-K92657060
Compound Name: zaleplon
Targets: GABRA1|GABRB1|GABRG2|TSPO
MoA: benzodiazepine receptor agonist
SMILES: CCN(C(C)=O)c1cccc(c1)-c1ccnc2c(cnn12)C#N
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
97164 BRD-K92657060 A375 1.11 uM 24 h -0.27 -1.13 0.4 0.0 0.0 0.0
97229 BRD-K92657060 PC3 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
128200 BRD-K92657060 MCF10A 0.37 uM 24 h 0.0 0.0 0.0 -0.34 -1.13 0.99
128279 BRD-K92657060 MDAMB231 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
135768 BRD-K92657060 A549 2.22 uM 24 h 0.0 0.0 0.0 0.27 0.95 0.31
135790 BRD-K92657060 HA1E 0.08 uM 24 h 0.31 1.3 0.69 -0.33 -1.12 0.95
135836 BRD-K92657060 HEK293 0.03 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
135875 BRD-K92657060 HELA 0.25 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
135928 BRD-K92657060 HT29 0.01 uM 24 h 0.0 0.0 0.0 0.31 1.08 0.65
135963 BRD-K92657060 JURKAT 2.22 uM 24 h 0.0 0.0 0.0 0.26 0.91 0.23
136017 BRD-K92657060 MCF??7.00 0.01 uM 24 h 0.0 0.0 0.0 -0.33 -1.12 0.93
136078 BRD-K92657060 THP1 0.08 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
136109 BRD-K92657060 YAPC 0.01 uM 24 h 0.0 0.0 0.0 -0.24 -0.8 0.12
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).