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CMap Candidate Details

Structure:
CMap ID: C05896
Pert ID: BRD-K37561857
Compound Name: zardaverine
Targets: PDE4D
MoA: phosphodiesterase inhibitor
SMILES: COc1cc(ccc1OC(F)F)-c1ccc(=O)[nH]n1
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
3191 BRD-K37561857 HCC515 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
3785 BRD-K37561857 VCAP 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
39687 BRD-K37561857 ASC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
39997 BRD-K37561857 HEPG2 10 uM 6 h -0.2 -0.81 0.0 0.0 0.0 0.0
40804 BRD-K37561857 NEU 10 uM 24 h 0.0 0.0 0.0 -0.3 -1.01 0.56
41107 BRD-K37561857 NPC 10 uM 24 h 0.0 0.0 0.0 -0.33 -1.11 0.9
41442 BRD-K37561857 SKB 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
91408 BRD-K37561857 HUH7 12.5 uM 72 h 0.0 0.0 0.0 0.0 0.0 0.0
99901 BRD-K37561857 U2OS 20 uM 6 h 0.21 0.88 0.01 0.0 0.0 0.0
123223 BRD-K37561857 A375 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
123257 BRD-K37561857 A549 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
123300 BRD-K37561857 HELA 0.37 uM 24 h 0.23 0.95 0.06 -0.25 -0.84 0.18
123410 BRD-K37561857 PC3 0.125 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
123445 BRD-K37561857 THP1 1.11 uM 24 h 0.19 0.78 0.0 0.0 0.0 0.0
123479 BRD-K37561857 YAPC 0.37 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
131571 BRD-K37561857 HA1E 0.01 uM 24 h 0.0 0.0 0.0 0.31 1.09 0.67
131608 BRD-K37561857 HEK293 0.01 uM 24 h -0.31 -1.3 0.8 0.0 0.0 0.0
131675 BRD-K37561857 HT29 0.08 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
131701 BRD-K37561857 HUVEC 0.74 uM 24 h 0.0 0.0 0.0 -0.3 -1.01 0.56
131754 BRD-K37561857 JURKAT 0.03 uM 24 h 0.24 0.99 0.1 0.0 0.0 0.0
131809 BRD-K37561857 MCF10A 0.74 uM 24 h 0.0 0.0 0.0 -0.25 -0.85 0.19
131838 BRD-K37561857 MCF??7.00 0.03 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
131878 BRD-K37561857 MDAMB231 2.22 uM 24 h 0.0 0.0 0.0 0.31 1.09 0.67
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).