CKDkb: a knowledge base and platform for drug development against non-alcoholic fatty liver disease

Structure:

CMap ID:	C05912
Pert ID:	BRD-K29582115
Compound Name:	ziprasidone
Targets:	ADRA1A\|ADRA1B\|ADRA2A\|ADRA2B\|ADRA2C\|CHRM1\|CHRM2\|CHRM3\|CHRM4\|CHRM5\|DRD1\|DRD2\|DRD3\|DRD4\|DRD5\|HRH1\|HTR1A\|HTR1B\|HTR1D\|HTR1E\|HTR2A\|HTR2C\|HTR3A\|HTR6\|HTR7\|SLC6A4
MoA:	dopamine receptor antagonist; serotonin receptor antagonist
SMILES:	Clc1cc2NC(=O)Cc2cc1CCN1CCN(CC1)c1nsc2ccccc12
InchiKey:
Compound Aliases:

The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).
Score ID	Pert ID	Cell Line	Pert Dose	Pert Time	Raw Score (GSE126848)	Normalized Score (GSE126848)	fdr_q_nlog10 (GSE126848)	Raw Score (GSE135251)	Normalized Score (GSE135251)	fdr_q_nlog10 (GSE135251)
1419	BRD-K29582115	NPC	25 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
34075	BRD-K29582115	ASC	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
34590	BRD-K29582115	HCC515	10 uM	6 h	0.0	0.0	0.0	-0.31	-1.03	0.62
34860	BRD-K29582115	HEPG2	10 uM	6 h	0.0	0.0	0.0	0.0	0.0	0.0
36237	BRD-K29582115	PHH	10 uM	24 h	-0.31	-1.31	0.82	0.24	0.85	0.15
36531	BRD-K29582115	SKB	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
36800	BRD-K29582115	VCAP	10 uM	24 h	0.0	0.0	0.0	0.35	1.22	1.18
119954	BRD-K29582115	A375	10 uM	24 h	0.0	0.0	0.0	0.4	1.41	2.18
119998	BRD-K29582115	A549	0.37 uM	24 h	0.0	0.0	0.0	0.33	1.15	0.9
120059	BRD-K29582115	HELA	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
120114	BRD-K29582115	HT29	0.04 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
120157	BRD-K29582115	MCF??7.00	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
120218	BRD-K29582115	YAPC	10 uM	24 h	-0.19	-0.81	0.0	0.0	0.0	0.0
128817	BRD-K29582115	HA1E	2.22 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
128850	BRD-K29582115	PC3	0.08 uM	24 h	0.0	0.0	0.0	-0.33	-1.12	0.95

Summary