CKDkb: a knowledge base and platform for drug development against non-alcoholic fatty liver disease

Structure:

CMap ID:	C05915
Pert ID:	BRD-K33882852
Compound Name:	ZK-93423
Targets:	GABRA1\|GABRA2\|GABRA3\|GABRA5\|GABRB2\|GABRG2
MoA:	benzodiazepine receptor agonist
SMILES:	CCOC(=O)c1ncc2[nH]c3ccc(OCc4ccccc4)cc3c2c1COC
InchiKey:
Compound Aliases:

The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).
Score ID	Pert ID	Cell Line	Pert Dose	Pert Time	Raw Score (GSE126848)	Normalized Score (GSE126848)	fdr_q_nlog10 (GSE126848)	Raw Score (GSE135251)	Normalized Score (GSE135251)	fdr_q_nlog10 (GSE135251)
3355	BRD-K33882852	HCC515	10 uM	6 h	-0.19	-0.79	0.0	0.35	1.23	1.23
3772	BRD-K33882852	VCAP	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
46050	BRD-K33882852	NPC	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
46685	BRD-K33882852	SKB	10 uM	24 h	-0.25	-1.03	0.19	0.0	0.0	0.0
53393	BRD-K33882852	HEPG2	2.5 uM	24 h	0.0	0.0	0.0	-0.33	-1.12	0.93
53507	BRD-K33882852	HUH7	10 uM	24 h	0.0	0.0	0.0	-0.37	-1.24	1.35
53655	BRD-K33882852	PHH	2.5 uM	24 h	-0.22	-0.92	0.06	0.27	0.94	0.29
99861	BRD-K33882852	U2OS	10 uM	6 h	0.2	0.85	0.01	-0.3	-1.01	0.58
120564	BRD-K33882852	A549	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
120601	BRD-K33882852	HA1E	10 uM	24 h	0.0	0.0	0.0	-0.24	-0.82	0.15
120625	BRD-K33882852	HELA	3.33 uM	24 h	0.0	0.0	0.0	-0.27	-0.91	0.31
120667	BRD-K33882852	HT29	0.04 uM	24 h	0.0	0.0	0.0	0.26	0.93	0.26
120719	BRD-K33882852	JURKAT	1.11 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
120758	BRD-K33882852	MCF??7.00	1.11 uM	24 h	0.26	1.09	0.24	0.0	0.0	0.0
120828	BRD-K33882852	YAPC	10 uM	24 h	0.0	0.0	0.0	-0.36	-1.22	1.25
128988	BRD-K33882852	A375	2.22 uM	24 h	0.0	0.0	0.0	-0.32	-1.07	0.75
129081	BRD-K33882852	PC3	2.22 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0

Summary