Logo 1 Logo 2

CMap Candidate Details

Structure:
CMap ID: C05938
Pert ID: BRD-K70557564
Compound Name: zosuquidar
Targets: ABCB1|ABCB4
MoA: P glycoprotein inhibitor
SMILES: O[C@@H](COc1cccc2ncccc12)CN1CCN(CC1)[C@@H]1c2ccccc2[C@@H]2[C@H](c3ccccc13)C2(F)F
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
34164 BRD-K70557564 ASC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
34670 BRD-K70557564 HCC515 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
34944 BRD-K70557564 HEPG2 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
35609 BRD-K70557564 NEU 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
35829 BRD-K70557564 NPC 10 uM 24 h -0.18 -0.76 0.0 -0.4 -1.34 1.85
36332 BRD-K70557564 PHH 10 uM 24 h 0.0 0.0 0.0 -0.39 -1.3 1.59
36629 BRD-K70557564 SKB 10 uM 24 h 0.26 1.1 0.24 0.0 0.0 0.0
36859 BRD-K70557564 VCAP 10 uM 24 h -0.25 -1.05 0.24 0.21 0.75 0.04
126366 BRD-K70557564 A375 10 uM 24 h 0.0 0.0 0.0 -0.41 -1.37 2.02
126385 BRD-K70557564 A549 10 uM 24 h -0.26 -1.07 0.27 0.3 1.06 0.59
126407 BRD-K70557564 HA1E 10 uM 24 h 0.19 0.8 0.0 0.0 0.0 0.0
126451 BRD-K70557564 HEK293 10 uM 24 h 0.29 1.19 0.42 -0.35 -1.19 1.15
126481 BRD-K70557564 HELA 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
126499 BRD-K70557564 HT29 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
126542 BRD-K70557564 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 -0.2 -0.67 0.02
126583 BRD-K70557564 PC3 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
126612 BRD-K70557564 YAPC 10 uM 24 h 0.23 0.96 0.07 0.2 0.72 0.03
134518 BRD-K70557564 HUVEC 2.22 uM 24 h 0.0 0.0 0.0 0.24 0.85 0.14
134544 BRD-K70557564 MCF10A 0.01 uM 24 h -0.28 -1.16 0.47 -0.32 -1.08 0.81
134607 BRD-K70557564 MDAMB231 0.08 uM 24 h 0.3 1.23 0.5 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).