Logo 1 Logo 2

CMap Candidate Details

Structure:
CMap ID: C05968
Pert ID: BRD-K63784565
Compound Name: 10-hydroxycamptothecin
Targets: TOP1
MoA: topoisomerase inhibitor
SMILES: CC[C@@]1(O)C(=O)OCc2c1cc1-c3nc4ccc(O)cc4cc3Cn1c2=O
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
44428 BRD-K63784565 A375 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
44603 BRD-K63784565 A549 10 uM 24 h 0.0 0.0 0.0 0.24 0.84 0.13
45002 BRD-K63784565 ASC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
45293 BRD-K63784565 HEPG2 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
45556 BRD-K63784565 HT29 10 uM 6 h 0.0 0.0 0.0 -0.33 -1.1 0.86
45838 BRD-K63784565 MCF??7.00 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
46115 BRD-K63784565 NPC 10 uM 24 h 0.0 0.0 0.0 0.4 1.42 2.19
46430 BRD-K63784565 PHH 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
46755 BRD-K63784565 SKB 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
99323 BRD-K63784565 U2OS 10 uM 6 h 0.25 1.03 0.14 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).