CKDkb: a knowledge base and platform for drug development against non-alcoholic fatty liver disease

Structure:

CMap ID:	C00716
Pert ID:	BRD-K45275534
Compound Name:	betrixaban
Targets:	KCNH2
MoA:	coagulation factor inhibitor
SMILES:	COc1ccc(NC(=O)c2ccc(cc2)C(=N)N(C)C)c(c1)C(=O)Nc1ccc(Cl)cn1
InchiKey:
Compound Aliases:

The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).
Score ID	Pert ID	Cell Line	Pert Dose	Pert Time	Raw Score (GSE126848)	Normalized Score (GSE126848)	fdr_q_nlog10 (GSE126848)	Raw Score (GSE135251)	Normalized Score (GSE135251)	fdr_q_nlog10 (GSE135251)
127028	BRD-K45275534	A375	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
127049	BRD-K45275534	HA1E	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
127077	BRD-K45275534	HEK293	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
127111	BRD-K45275534	HELA	10 uM	24 h	0.0	0.0	0.0	0.28	1.0	0.42
127147	BRD-K45275534	HT29	3.33 uM	24 h	0.2	0.83	0.0	0.35	1.22	1.16
127188	BRD-K45275534	MCF10A	10 uM	24 h	0.0	0.0	0.0	-0.3	-1.02	0.61
127217	BRD-K45275534	MCF??7.00	0.04 uM	24 h	0.26	1.06	0.19	0.0	0.0	0.0
127288	BRD-K45275534	THP1	3.33 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
135055	BRD-K45275534	A549	0.74 uM	24 h	-0.21	-0.87	0.02	0.39	1.38	2.17
135181	BRD-K45275534	JURKAT	0.03 uM	24 h	-0.22	-0.9	0.04	-0.26	-0.89	0.26
135279	BRD-K45275534	MDAMB231	0.03 uM	24 h	0.0	0.0	0.0	-0.32	-1.07	0.77
135300	BRD-K45275534	PC3	0.74 uM	24 h	-0.23	-0.95	0.09	0.0	0.0	0.0
135331	BRD-K45275534	YAPC	0.01 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0

Summary