CKDkb: a knowledge base and platform for drug development against non-alcoholic fatty liver disease

Structure:

CMap ID:	C00717
Pert ID:	BRD-K45401373
Compound Name:	betulinic-acid
Targets:	GPBAR1
MoA:	apoptosis stimulant; NFkB pathway inhibitor
SMILES:	CC(=C)[C@@H]1CC[C@@]2(CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CC[C@H](O)C(C)(C)[C@@H]5CC[C@@]34C)[C@@H]12)C(O)=O
InchiKey:
Compound Aliases:

The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).
Score ID	Pert ID	Cell Line	Pert Dose	Pert Time	Raw Score (GSE126848)	Normalized Score (GSE126848)	fdr_q_nlog10 (GSE126848)	Raw Score (GSE135251)	Normalized Score (GSE135251)	fdr_q_nlog10 (GSE135251)
3207	BRD-K45401373	HCC515	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
3805	BRD-K45401373	VCAP	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
39701	BRD-K45401373	ASC	10 uM	24 h	0.0	0.0	0.0	0.25	0.89	0.21
40817	BRD-K45401373	NEU	10 uM	24 h	-0.3	-1.24	0.65	0.22	0.79	0.07
41121	BRD-K45401373	NPC	10 uM	24 h	0.0	0.0	0.0	-0.22	-0.75	0.06
41456	BRD-K45401373	SKB	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
115644	BRD-K45401373	A375	10 uM	24 h	0.0	0.0	0.0	0.27	0.96	0.34
115681	BRD-K45401373	A549	10 uM	24 h	-0.29	-1.19	0.53	-0.24	-0.82	0.15
115720	BRD-K45401373	HA1E	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
115806	BRD-K45401373	HEPG2	10 uM	24 h	-0.22	-0.94	0.07	-0.37	-1.26	1.36
115853	BRD-K45401373	HT29	0.37 uM	24 h	-0.31	-1.3	0.81	0.0	0.0	0.0
115891	BRD-K45401373	MCF??7.00	3.33 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
115931	BRD-K45401373	PC3	10 uM	24 h	-0.18	-0.75	0.0	0.23	0.82	0.1

Summary