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CMap Candidate Details

Structure:
CMap ID: C00723
Pert ID: BRD-K29415052
Compound Name: BGT226
Targets: MTOR|PIK3CA|PIK3CB|PIK3CG
MoA: PI3K inhibitor
SMILES: COc1ccc(cn1)-c1ccc2ncc3n(C)c(=O)n(-c4ccc(N5CCNCC5)c(c4)C(F)(F)F)c3c2c1
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
92879 BRD-K29415052 A375 0.37 uM 24 h 0.27 1.14 0.32 -0.21 -0.71 0.03
92906 BRD-K29415052 A549 0.12 uM 24 h 0.0 0.0 0.0 -0.25 -0.85 0.19
92962 BRD-K29415052 ASC 10 uM 24 h 0.25 1.06 0.18 0.0 0.0 0.0
93017 BRD-K29415052 CD34 0.12 uM 24 h 0.3 1.25 0.56 -0.31 -1.03 0.65
93054 BRD-K29415052 HA1E 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
93103 BRD-K29415052 HEK293 3.33 uM 24 h 0.0 0.0 0.0 -0.27 -0.9 0.28
93144 BRD-K29415052 HELA 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
93186 BRD-K29415052 HEPG2 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
93243 BRD-K29415052 HUVEC 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
93294 BRD-K29415052 JURKAT 0.37 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
93330 BRD-K29415052 MCF10A 10 uM 24 h 0.0 0.0 0.0 -0.25 -0.86 0.21
93372 BRD-K29415052 MDAMB231 3.33 uM 24 h 0.0 0.0 0.0 -0.29 -0.97 0.46
93431 BRD-K29415052 NPC 0.04 uM 24 h 0.0 0.0 0.0 -0.43 -1.44 15.35
93461 BRD-K29415052 PC3 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
93498 BRD-K29415052 SKL 3.33 uM 24 h 0.0 0.0 0.0 -0.26 -0.88 0.25
93558 BRD-K29415052 THP1 3.33 uM 24 h 0.0 0.0 0.0 -0.25 -0.84 0.18
93599 BRD-K29415052 YAPC 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).