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CMap Candidate Details

Structure:
CMap ID: C00727
Pert ID: BRD-K64890080
Compound Name: BI-2536
Targets: BRD4|PLK1|PLK2|PLK3
MoA: PLK inhibitor
SMILES: CC[C@H]1N(C2CCCC2)c2nc(Nc3ccc(cc3OC)C(=O)NC3CCN(C)CC3)ncc2N(C)C1=O
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
1322 BRD-K64890080 U2OS 0.12 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
9473 BRD-K64890080 AGS 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
10174 BRD-K64890080 HCC515 10 uM 24 h 0.0 0.0 0.0 0.37 1.3 1.49
10561 BRD-K64890080 HCT116 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
10821 BRD-K64890080 HEPG2 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
11538 BRD-K64890080 NCIH2073 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
11807 BRD-K64890080 NCIH508 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
12099 BRD-K64890080 NCIH596 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
12358 BRD-K64890080 NOMO1 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
12838 BRD-K64890080 SW480 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
13015 BRD-K64890080 THP1 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
13324 BRD-K64890080 U937 10 uM 6 h 0.2 0.82 0.0 -0.24 -0.81 0.14
13493 BRD-K64890080 VCAP 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
91550 BRD-K64890080 BT20 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
91661 BRD-K64890080 MCF??7.00 0.08 uM 24 h 0.0 0.0 0.0 -0.36 -1.23 1.25
92492 BRD-K64890080 HA1E 3.33 uM 24 h 0.29 1.21 0.46 -0.23 -0.79 0.1
92524 BRD-K64890080 HME1 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
92604 BRD-K64890080 HS578T 0.37 uM 3 h 0.0 0.0 0.0 -0.33 -1.13 0.97
92623 BRD-K64890080 HT29 0.04 uM 24 h 0.0 0.0 0.0 -0.28 -0.96 0.43
92657 BRD-K64890080 LNCAP 0.04 uM 24 h 0.28 1.16 0.35 0.0 0.0 0.0
92711 BRD-K64890080 MCF10A 0.04 uM 24 h 0.0 0.0 0.0 -0.33 -1.12 0.95
92800 BRD-K64890080 PC3 0.04 uM 24 h 0.0 0.0 0.0 -0.36 -1.2 1.22
92846 BRD-K64890080 SKBR3 0.37 uM 3 h 0.0 0.0 0.0 0.0 0.0 0.0
96002 BRD-K64890080 PHH 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
97248 BRD-K64890080 HAP1 0.66 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
125032 BRD-K64890080 HELA 3.33 uM 24 h 0.0 0.0 0.0 -0.27 -0.89 0.27
132982 BRD-K64890080 A375 0.25 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
132997 BRD-K64890080 A549 0.03 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
133058 BRD-K64890080 HEK293 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
133165 BRD-K64890080 JURKAT 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
133265 BRD-K64890080 MDAMB231 0.03 uM 24 h 0.0 0.0 0.0 -0.25 -0.85 0.19
133319 BRD-K64890080 YAPC 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).