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CMap Candidate Details

Structure:
CMap ID: C00734
Pert ID: BRD-K70914287
Compound Name: BIBX-1382
Targets: EGFR|ERBB2
MoA: EGFR inhibitor
SMILES: CN1CCC(CC1)Nc1ncc2ncnc(Nc3ccc(F)c(Cl)c3)c2n1
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
5679 BRD-K70914287 HCC515 10 uM 24 h 0.0 0.0 0.0 0.33 1.18 0.97
6585 BRD-K70914287 VCAP 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
37726 BRD-K70914287 ASC 10 uM 24 h 0.25 1.05 0.17 -0.25 -0.84 0.18
37939 BRD-K70914287 HEPG2 10 uM 6 h -0.21 -0.87 0.02 0.0 0.0 0.0
38545 BRD-K70914287 NPC 10 uM 24 h -0.25 -1.06 0.26 0.27 0.97 0.34
38769 BRD-K70914287 PHH 10 uM 24 h 0.0 0.0 0.0 0.27 0.97 0.35
38997 BRD-K70914287 SKB 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
97313 BRD-K70914287 HAP1 3.33 uM 24 h -0.29 -1.21 0.58 0.31 1.1 0.7
99411 BRD-K70914287 U2OS 10 uM 6 h 0.0 0.0 0.0 0.27 0.94 0.3
126432 BRD-K70914287 HEK293 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
126474 BRD-K70914287 HELA 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
126492 BRD-K70914287 HT29 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
126520 BRD-K70914287 MCF10A 10 uM 24 h 0.26 1.07 0.2 0.0 0.0 0.0
126536 BRD-K70914287 MCF??7.00 10 uM 24 h 0.34 1.41 1.03 0.33 1.18 0.97
126598 BRD-K70914287 YAPC 10 uM 24 h 0.0 0.0 0.0 0.33 1.16 0.9
134344 BRD-K70914287 A375 2.22 uM 24 h 0.19 0.78 0.0 -0.3 -1.0 0.52
134372 BRD-K70914287 A549 2.22 uM 24 h 0.0 0.0 0.0 -0.28 -0.93 0.35
134397 BRD-K70914287 HA1E 2.22 uM 24 h 0.0 0.0 0.0 -0.34 -1.13 0.98
134498 BRD-K70914287 HUVEC 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
134594 BRD-K70914287 MDAMB231 2.22 uM 24 h 0.23 0.98 0.09 -0.24 -0.82 0.15
134622 BRD-K70914287 PC3 0.03 uM 24 h 0.21 0.87 0.01 -0.27 -0.91 0.31
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).