CMap Candidate Details
Structure:
| CMap ID: | C00746 |
| Pert ID: | BRD-A45153512 |
| Compound Name: | bimatoprost |
| Targets: | AKR1C3|PTGER1|PTGER3|PTGFR |
| MoA: | prostanoid receptor agonist |
| SMILES: | CCNC(=O)CCC\C=C/C[C@H]1[C@@H](O)C[C@@H](O)[C@@H]1\C=C\C(O)CCc1ccccc1 |
| InchiKey: | |
| Compound Aliases: |
| Score ID | Pert ID | Cell Line | Pert Dose | Pert Time | Raw Score (GSE126848) | Normalized Score (GSE126848) | fdr_q_nlog10 (GSE126848) | Raw Score (GSE135251) | Normalized Score (GSE135251) | fdr_q_nlog10 (GSE135251) |
|---|---|---|---|---|---|---|---|---|---|---|
| 125585 | BRD-A45153512 | A375 | 0.37 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 125614 | BRD-A45153512 | A549 | 0.04 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 125654 | BRD-A45153512 | HEK293 | 0.37 uM | 24 h | 0.3 | 1.26 | 0.56 | -0.29 | -0.96 | 0.44 |
| 125737 | BRD-A45153512 | HUVEC | 10 uM | 24 h | 0.0 | 0.0 | 0.0 | -0.35 | -1.19 | 1.15 |
| 125853 | BRD-A45153512 | MDAMB231 | 0.125 uM | 24 h | 0.25 | 1.03 | 0.14 | 0.0 | 0.0 | 0.0 |
| 125876 | BRD-A45153512 | PC3 | 0.04 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 125935 | BRD-A45153512 | YAPC | 0.125 uM | 24 h | 0.27 | 1.11 | 0.25 | 0.0 | 0.0 | 0.0 |
| 133701 | BRD-A45153512 | HA1E | 2.22 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 133769 | BRD-A45153512 | HELA | 0.74 uM | 24 h | 0.33 | 1.36 | 0.97 | 0.21 | 0.75 | 0.04 |
| 133801 | BRD-A45153512 | HT29 | 0.01 uM | 24 h | -0.23 | -0.97 | 0.11 | 0.0 | 0.0 | 0.0 |
| 133827 | BRD-A45153512 | JURKAT | 0.03 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.37 | 1.32 | 1.71 |
| 133859 | BRD-A45153512 | MCF10A | 0.08 uM | 24 h | -0.25 | -1.05 | 0.23 | 0.0 | 0.0 | 0.0 |
| 133885 | BRD-A45153512 | MCF??7.00 | 0.03 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 133981 | BRD-A45153512 | THP1 | 0.74 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.3 | 1.05 | 0.58 |