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CMap Candidate Details

Structure:
CMap ID: C00772
Pert ID: BRD-K26818574
Compound Name: BIX-01294
Targets: EHMT1|EHMT2
MoA: histone lysine methyltransferase inhibitor
SMILES: COc1cc2nc(nc(NC3CCN(Cc4ccccc4)CC3)c2cc1OC)N1CCCN(C)CC1
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
1457 BRD-K26818574 NPC 4 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
27268 BRD-K26818574 HT29 10 uM 6 h 0.0 0.0 0.0 -0.54 -1.82 15.65
27531 BRD-K26818574 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
28842 BRD-K26818574 PHH 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
29166 BRD-K26818574 SKB 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
29456 BRD-K26818574 VCAP 10 uM 24 h 0.0 0.0 0.0 0.27 0.96 0.34
93617 BRD-K26818574 A549 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
93655 BRD-K26818574 ASC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
93717 BRD-K26818574 CD34 1.11 uM 24 h 0.2 0.85 0.01 0.26 0.92 0.25
93844 BRD-K26818574 HEK293 10 uM 24 h 0.26 1.07 0.2 0.0 0.0 0.0
93888 BRD-K26818574 HELA 10 uM 24 h 0.19 0.8 0.0 0.0 0.0 0.0
93928 BRD-K26818574 HEPG2 10 uM 24 h 0.19 0.79 0.0 0.0 0.0 0.0
93963 BRD-K26818574 HUVEC 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
94028 BRD-K26818574 JURKAT 0.37 uM 24 h 0.29 1.2 0.43 0.37 1.32 1.64
94240 BRD-K26818574 SHSY5Y 10 uM 24 h 0.0 0.0 0.0 0.33 1.18 0.98
94292 BRD-K26818574 SKL 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
94339 BRD-K26818574 THP1 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
95913 BRD-K26818574 YAPC 10 uM 6 h 0.0 0.0 0.0 -0.31 -1.04 0.67
97074 BRD-K26818574 PC3 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
98361 BRD-K26818574 NEU 10 uM 24 h 0.24 1.01 0.12 -0.45 -1.51 15.35
118388 BRD-K26818574 A375 10 uM 24 h -0.2 -0.85 0.01 0.0 0.0 0.0
118458 BRD-K26818574 HA1E 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
118500 BRD-K26818574 HCC515 3.33 uM 24 h 0.0 0.0 0.0 0.31 1.1 0.69
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).