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CMap Candidate Details

Structure:
CMap ID: C00774
Pert ID: BRD-K73368362
Compound Name: BIX-02189
Targets: MAP2K5|MAPK7
MoA: MEK inhibitor
SMILES: CN(C)Cc1cccc(N\C(c2ccccc2)=C2/C(=O)Nc3cc(ccc23)C(=O)N(C)C)c1
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
88501 BRD-K73368362 VCAP 10 uM 24 h 0.3 1.23 0.5 0.0 0.0 0.0
91829 BRD-K73368362 HS578T 2.22 uM 6 h -0.21 -0.89 0.04 0.0 0.0 0.0
91883 BRD-K73368362 MCF??7.00 10 uM 6 h -0.19 -0.79 0.0 -0.28 -0.96 0.42
91972 BRD-K73368362 SKBR3 2.22 uM 6 h 0.0 0.0 0.0 0.34 1.21 1.13
92862 BRD-K73368362 A375 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
92889 BRD-K73368362 A549 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
92921 BRD-K73368362 ASC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
92981 BRD-K73368362 CD34 10 uM 24 h -0.32 -1.34 0.98 0.0 0.0 0.0
93034 BRD-K73368362 HA1E 0.12 uM 24 h 0.3 1.24 0.51 -0.21 -0.71 0.03
93071 BRD-K73368362 HEK293 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
93118 BRD-K73368362 HELA 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
93158 BRD-K73368362 HEPG2 10 uM 24 h -0.21 -0.89 0.03 0.0 0.0 0.0
93207 BRD-K73368362 HUVEC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
93264 BRD-K73368362 JURKAT 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
93306 BRD-K73368362 MCF10A 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
93347 BRD-K73368362 MDAMB231 0.37 uM 24 h 0.0 0.0 0.0 -0.39 -1.32 1.71
93389 BRD-K73368362 NPC 10 uM 24 h 0.22 0.92 0.04 0.0 0.0 0.0
93439 BRD-K73368362 PC3 10 uM 24 h -0.27 -1.13 0.41 0.0 0.0 0.0
93508 BRD-K73368362 SKL 10 uM 24 h 0.0 0.0 0.0 0.28 0.98 0.39
93534 BRD-K73368362 THP1 10 uM 24 h 0.0 0.0 0.0 -0.33 -1.1 0.88
93574 BRD-K73368362 YAPC 10 uM 24 h 0.22 0.91 0.04 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).